Aldose reductase-deficient mice develop nephrogenic diabetes insipidus
Aldose reductase-deficient mice develop nephrogenic diabetes insipidus
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DOI：
10.1128/mcb.20.16.5840-5846.2000
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发表时间：
2000-08-01
影响因子：
5.3
通讯作者：
Chung, SSM
中科院分区：
文献类型：
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作者：
Ho, HTB;Chung, SK;Chung, SSM
醛糖还原酶(ALR2)被认为与多种糖尿病相关疾病的发病机制有关，如白内障、视网膜病变、神经病变和肾病等，但其生理功能尚不清楚。我们培育了这种酶缺陷的小鼠，发现它们没有明显的发育或生殖异常，除了饮酒和排尿明显多于它们的野生型后代外，这些ALR2基因缺陷的小鼠表现出部分的尿液浓缩能力缺陷，具有类似肾源性尿崩症的表型。
Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy, However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates, These ALR2-deficient mice exhibited a partially defective urine concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.