Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant.
Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant.
复制标题
Jarvik 2000 植入后因获得性冯维勒布兰德综合征而出现顽固性出血倾向。
DOI：
10.1007/s10047-016-0896-7
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发表时间：
2016
影响因子：
1.3
通讯作者：
Saiki Y.
中科院分区：
文献类型：
--
作者：
Sakatsume K;Akiyama M;Saito K;Kawamoto S;Horiuchi H;Saiki Y.
一名 61 岁男性因扩张型心肌病导致终末期心力衰竭，被植入 Jarvik 2000，这是一种连续轴流式左心室辅助装置 (LVAD)。一个月后，他的术后病程因结肠多发小浅溃疡和糜烂而出现顽固性渗出型胃肠道出血。此外，胸腔积液胸腔穿刺部位周围也出现反复出血。血液学检查显示血小板计数和凝血因子保持在正常范围内。此后，我们发现血管性血友病因子（VWF）的大量多聚体显着丢失，这可能与他的顽固性出血倾向密切相关。
A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.