Antioxidant enzyme activities and malondialdehyde levels related to aging
Antioxidant enzyme activities and malondialdehyde levels related to aging
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DOI：
10.1016/s0009-8981(00)00422-8
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发表时间：
2001-03-01
影响因子：
5
通讯作者：
Sunal, E
中科院分区：
文献类型：
--
作者：
Inal, ME;Kanbak, G;Sunal, E
背景：氧自由基被认为是衰老的重要原因。我们评估了抗氧化酶活性和脂质过氧化的年龄相关变化。方法：测定红细胞超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）及血浆丙二醛（MDA）含量。将176名健康受试者分为5组：第1组（n=25; 0.2-1岁），第2组（n=28; 2-11岁），第3组（n =23：12-24岁），第4组（n =40; 25-40岁），第5组（n =60：41-69岁）。结果：第5组SOD活性明显低于其他各组（P
Background: Free oxygen radicals have been proposed as important causative agents of aging. We have evaluated age-related changes in antioxidant enzyme activities and lipid peroxidation. Methods: We measured erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and plasma malondialdehyde (MDA) levels. One hundred and seventy six healthy subjects were divided into five groups:Group 1 (n=25; 0.2-1 year-old), Group 2 (n=28; 2-11 years), Group 3 (n =23: 12-24 years), Group 4 (n =40; 25-40 years), Group 5 (n =60: 41-69 years). Results: SOD activities in Group 5 were significantly lower than in the other groups (P