TRANSMISSION OF SCRAPIE TO CYNOMOLGUS MONKEY (MACACA-FASCICULARIS)
TRANSMISSION OF SCRAPIE TO CYNOMOLGUS MONKEY (MACACA-FASCICULARIS)
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DOI：
10.1038/236073a0
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发表时间：
1972-01-01
期刊：
影响因子：
64.8
通讯作者：
GAJDUSEK, DC
中科院分区：
文献类型：
--
作者：
GIBBS, CJ;GAJDUSEK, DC
瘙痒病已传播给食蟹猴（Macaca fasciculis），从感染瘙痒病的小鼠脑部进行脑内接种起，潜伏期超过 5 年。该动物出现慢性中枢神经系统变性，伴有共济失调、震颤和肌阵挛，并伴有星形胶质细胞密集肥大和增殖、神经元空泡化和灰质海绵状状态的严重痒病样病理。使用的痒病病毒株是瑞士小鼠（NIH）中第八次传代的康普顿痒病株，该病毒株是在山羊大脑中第九次脑内传代而获得的，来自 R. L. Chandler 博士（ARC，康普顿，伯克郡）。
SCRAPIE has been transmitted to the cynomolgus, or crab-eating, monkey (Macaca fascicularis) with an incubation period of more than 5 yr from the time of intracerebral inoculation of scrapie-infected mouse brain. The animal developed a chronic central nervous system degeneration, with ataxia, tremor and myoclonus with associated severe scrapie-like pathology of intensive astroglial hypertrophy and proliferation, neuronal vacuolation and status spongiosus of grey matter. The strain of scrapie virus used was the eighth passage in Swiss mice (NIH) of a Compton strain of scrapie obtained as ninth intracerebral passage of the agent in goat brain, from Dr R. L. Chandler (ARC, Compton, Berkshire).