Reciprocal modulation and attenuation in the prefrontal cortex: An fMRI study on emotional-cognitive interaction
Reciprocal modulation and attenuation in the prefrontal cortex: An fMRI study on emotional-cognitive interaction
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DOI：
10.1002/hbm.20002
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发表时间：
2004-03-01
影响因子：
4.8
通讯作者：
Schlaug, G
中科院分区：
文献类型：
--
作者：
Northoff, G;Heinzel, A;Schlaug, G
日常和临床经验表明情绪和认知之间存在很强的相互作用。然而，情绪认知相互作用背后的神经关联仍不清楚。使用事件相关的功能磁共振成像，我们研究了在对国际情感图片系统（IAPS）拍摄的照片进行情感和非情感判断时内侧和外侧前额皮质区域的 BOLD 信号增加和减少。将情绪和非情绪判断条件相互比较，并与基线进行比较，以区分相对信号变化（条件之间的比较）和真实信号变化（参考基线）。我们发现：（1）LAYS图片的情感和非情感判断的特征是位于腹侧和背侧的外侧前额皮质区域的信号增加，同时腹侧和背内侧前额皮质区域的信号减少。皮质； (2)情绪判断和非情绪判断的直接比较显示腹侧和背内侧前额皮质区域的相对信号增加，相反，当比较非情绪判断和情绪判断时，腹侧和背侧的外侧前额皮质区域检测到相对信号增加； (3)如与基线的单独比较所示，这些相对信号变化是由于在情绪判断过程中腹侧和背内侧前额皮质区域的信号减少较小，以及腹侧和背侧的外侧前额皮质区域的信号增加较小。因此，认知任务的情绪负荷会减少内侧前额叶区域的失活，同时减少外侧前额叶区域的激活。先前已经描述了其他皮质区域（例如视觉和听觉区域）的类似的相互调制和衰减模式。内侧和外侧前额叶皮层的相互调节和衰减可能构成在健康和精神病受试者中观察到的情绪认知相互作用的神经生理学基础。 (C) 2004 Wiley-Liss, Inc.
Everyday and clinical experience demonstrate strong interactions between emotions and cognitions. Nevertheless the neural correlates underlying emotional-cognitive interaction remain unclear. Using eventrelated fMRI, we investigated BOLD-signal increases and decreases in medial and lateral prefrontal cortical regions during emotional and non-emotional judgment of photographs taken from the International Affective Picture System (IAPS). Emotional and non-emotional judgment conditions were compared to each other as well as with baseline allowing for distinction between relative signal changes (comparison between conditions) and true signal changes (referring to baseline). We have found that: (1) both emotional and non-emotional judgment of LAYS pictures were characterized by signal increases in ventrally and dorsally located lateral prefrontal cortical areas and concurrent signal decreases in ventro- and dorsomedial prefrontal. cortex; (2) direct comparison between emotional and non-emotional judgment showed relative signal increases in ventro- and dorsomedial prefrontal cortex, and in contrast, relative signal increases were detected in ventrally and dorsally located lateral prefrontal cortical areas when comparing non-emotional to emotional judgment; and (3) as shown in separate comparisons with baseline, these relative signal changes were due to smaller signal decreases in ventro- and dorsomedial prefrontal cortex and smaller signal increases in ventrally and dorsally located lateral prefrontal cortical areas during emotional judgment. Therefore, the emotional load of a cognitive task lead to both less deactivation of medial prefrontal regions and, at the same time, less activation of lateral prefrontal regions. Analogous patterns of reciprocal modulation and attenuation have previously been described for other cortical regions such as visual and auditory areas. Reciprocal modulation and attenuation in medial and lateral prefrontal cortex might constitute the neurophysiologic basis for emotional-cognitive interaction as observed in both healthy and psychiatric subjects. (C) 2004 Wiley-Liss, Inc.