Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: An analysis of survival and treatment toxicities
Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: An analysis of survival and treatment toxicities
复制标题
DOI：
10.1016/j.radonc.2013.10.020
复制
发表时间：
2014-03-01
影响因子：
5.7
通讯作者：
Lu, Taixiang
中科院分区：
文献类型：
--
作者：
Sun, Xueming;Su, Shengfa;Lu, Taixiang
背景与目的：评价调强放疗（IMRT）治疗鼻咽癌患者的长期生存结局和毒性。材料与方法：回顾性分析2001年5月至2008年10月868例接受IMRT治疗的非转移性鼻咽癌患者的资料。采用放射治疗肿瘤组（RTOG）标准评估毒性。结果：中位随访50个月（范围5-115个月），5年估计疾病特异性生存率（DSS）、局部无复发生存率（LRFS）、区域无复发生存率（RRFS）和远处无转移生存率（DMFS）分别为84.7%、91.8%、96.4%和84.6%。在868例患者中，186例（21.3%）在治疗后出现衰竭。远处转移是治疗后的主要失败模式。I期、II期、II期和IVa-b期患者的5年OS率分别为100.0%、94.3%、83.6%和70.5%。T1期、T2期、T3期和T4期患者的5年LRFS率分别为100.0%、96.0%、90.4%和83.3% (chi(2)=2632， P
Background and purpose: To evaluate the long-term survival outcomes and toxicity of NPC patients treated with intensity-modulated radiotherapy (IMRT).Materials and methods: From May 2001 to October 2008, 868 non-metastatic NPC patients treated by IMRT were analyzed retrospectively. The Radiation Therapy Oncology Group (RTOG) criteria were used to assess toxicity.Results: With a median follow-up of 50 months (range, 5-115 months), the 5-year estimated disease specific survival (DSS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS) and distant metastasis-free survival (DMFS) were 84.7%, 91.8%, 96.4% and 84.6%, respectively. Of the 868 patients, 186 (21.3%) developed failure after treatment. Distant metastasis was the major failure pattern after treatment. The 5-year OS rate in patients with stage I, II, Ill, and IVa-b were 100.0%, 94.3%, 83.6%, and 70.5%, respectively. The 5-year LRFS rate in patients with stage T1, T2, T3, and T4 disease were 100.0%, 96.0%, 90.4%, and 83.3%, respectively (chi(2)=2632, P