Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.
Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.
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DOI：
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发表时间：
1995-10
影响因子：
9.8
通讯作者：
D. Luo;Marilyn M. Bui;Andrew Muir;Noel K. Maclaren;G. Thomson;Jin-Xiong She
中科院分区：
文献类型：
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作者：
D. Luo;Marilyn M. Bui;Andrew Muir;Noel K. Maclaren;G. Thomson;Jin-Xiong She
对104个高加索家族进行了受影响的兄弟姐妹对分析，以绘制易患胰岛素依赖性糖尿病（IDDM）的基因。我们已经获得了D6S446（最大负载评分[MLS] = 2.8）和D6S264 （MLS = 2.0）在6q25-q27上的连锁证据。结合先前报道的数据集，可以牢固地建立联系（D6S264的MLS = 3.4），并将疾病位点指定为IDDM8。通过对独立家族的分析，我们证实了先前确定的IDDM3 （15q）和DDM7 （2q）的连锁证据。我们还在包含IDDM3、IDDM4、IDDM5和IDDM8的区域输入了额外的标记。在佛罗里达州的47个家庭中发现了4q染色体上一个新区域（D4S1566）的初步连锁证据（P < .03）。我们还发现了先前在佛罗里达亚群中确定为潜在联系的两个区域的联系证据：D3S1303在3q （P < .04）和D7S486在7q （P < .03）。我们无法证实与其他8个区域（D1S191、D1S412、D4S1604、D8S264、D8S556、D10S193、D13S158和D18S64）的潜在关联。
Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage evidence for D6S446 (maximum lod score [MLS] = 2.8) and for D6S264 (MLS = 2.0) on 6q25-q27. Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has been designated IDDM8. With analysis of independent families, we confirmed linkage evidence for the previously identified IDDM3 (15q) and DDM7 (2q). We also typed additional markers in the regions containing IDDM3, IDDM4, IDDM5, and IDDM8. Preliminary linkage evidence for a novel region on chromosome 4q (D4S1566) has been found in 47 Florida families (P < .03). We also found evidence of linkage for two regions previously identified as potential linkages in the Florida subset: D3S1303 on 3q (P < .04) and D7S486 on 7q (P < .03). We could not confirm linkage with eight other regions (D1S191, D1S412, D4S1604, D8S264, D8S556, D10S193, D13S158, and D18S64) previously identified as potential linkages.