SITE-SPECIFIC PHASE-I, PHASE-II TRIALS OF HYPERTHERMIA AT KYOTO-UNIVERSITY
SITE-SPECIFIC PHASE-I, PHASE-II TRIALS OF HYPERTHERMIA AT KYOTO-UNIVERSITY
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DOI：
10.3109/02656739409010285
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发表时间：
1994-05-01
影响因子：
3.1
通讯作者：
KOISHI, M
中科院分区：
文献类型：
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作者：
HIRAOKA, M;NISHIMURA, Y;KOISHI, M
对京都大学进行的局部区域热疗的特定地点I、II期试验进行了简要回顾。测温分析证明了射频（射频）电容加热设备在治疗各种皮下或深部肿瘤中的有用性，包括局部晚期乳腺癌、软组织肿瘤、累及胸壁的肺癌、肝肿瘤、不可切除或复发性结直肠癌和浸润性膀胱癌。还显示了将整个肿瘤体积或多血管肿瘤加热到治疗温度的困难。局部晚期乳腺癌、不可切除或复发性结直肠癌和浸润性膀胱癌的非随机试验表明，热放疗的反应率高于单纯放疗。除了一项结肠直肠癌试验中的慢性肠损伤外，与治疗相关的并发症一般不严重。这些有希望的I、II期试验鼓励了未来的III期试验。
Site-specific phase I, II trials of locoregional hyperthermia undertaken at Kyoto University are briefly reviewed. Thermometry analysis demonstrated the usefulness of RF (radiofrequency) capacitive heating equipment in the treatment of various subsurface or deep-seated tumours including locally advanced breast cancers, soft tissue tumours, lung cancers involving the chest wall, liver tumours, unresectable or recurrent colorectal cancers, and invasive urinary bladder cancers. The difficulty in heating whole tumour volume or hypervascular tumours to therapeutic temperatures was also shown. Non-randomized trials for locally advanced breast cancers, unresectable or recurrent colorectal cancers and invasive urinary bladder cancers demonstrated a higher response rate in thermoradiotherapy than in radiotherapy alone. The complications associated with treatment were not generally serious except for chronic bowel damages in a trial for colorectal cancers. These promising phase I, II trials encourage the future phase III trials.