Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men
Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men
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DOI：
10.1016/j.nutres.2008.11.007
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发表时间：
2009-02-01
影响因子：
4.5
通讯作者：
Chalchi, Mohammad Javad
中科院分区：
文献类型：
--
作者：
Colagar, Abasalt Hosseinzadeh;Marzony, Eisa Tahmasbpour;Chalchi, Mohammad Javad
锌具有抗氧化特性，在清除活性氧中起重要作用。我们假设，在缺乏锌的情况下，存在氧化损伤增加的可能性，这将有助于精子质量差。因此，测量精液锌在精浆中的男性生育力低下或特发性不育症的历史是必要的，可以帮助生育力评估。本研究的主要目的是评估精浆锌水平与精子质量之间的关系在生育和不育男性。精液样本由生育男性（吸烟者[n = 17]，非吸烟者[n = 19]）和不育男性（吸烟者[n = 15]，非吸烟者[n = 2 1]）提供。精液分析后，用原子吸收光谱法测定各组精浆中锌、镁、钙、钠和钾的浓度。各组精浆中元素含量顺序为Na > K > Ca > Zn > Mg。生育者，无论是否吸烟，精液锌水平均显著高于不育组（P <0.001）。吸烟者精浆中锌水平较不吸烟者低。生育和不育（吸烟或不吸烟）男性精液锌与精子计数（P <0.01）和精子正常形态（P <0.001）显著相关。精浆锌与钙、钾含量呈显著正相关（P <0.01）。因此，锌营养不良可能是导致精子质量低下和特发性男性不育的重要危险因素。(c)2009 Elsevier Inc. All rights reserved.
Zinc has antioxidative properties and plays an important role in scavenging reactive oxygen species. We hypothesized that in the absence of Zn, the possibility of increased oxidative damage exists that would contribute to poor sperm quality. Therefore, measurement of seminal Zn in the seminal plasma of males with a history of subfertility or idiopathic infertility is necessary and can be helpful in fertility assessment. The primary objective of the present study was to assess the relationship between Zn levels in seminal plasma with sperm quality in fertile and infertile men. Semen samples were provided by fertile (smoker [n = 17], nonsmoker [n = 19]) and infertile men (smoker [n = 15], nonsmoker [n = 2 1]). After semen analysis, concentrations of Zn, Mg, Ca, Na, and K in the seminal plasma of all groups were determined by atomic absorption spectroscopy. Element concentrations in seminal plasma of all groups were in the order Na > K > Ca > Zn > Mg. Fertile subjects, smoker or not, demonstrated significantly higher seminal Zn levels than any infertile group (P < .001). A trend was observed for a lower Zn levels in seminal plasma of smokers compared with nonsmokers. Seminal Zn in fertile and infertile (smokers or nonsmokers) males correlated significantly with sperm count (P < .01) and normal morphology of sperm (P < .001). There was a significantly positive correlation between seminal Zn with Ca (P < .01) and K (P < .01) levels in all specimens. In conclusion, poor Zn nutrition may be an important risk factor for low quality of sperm and idiopathic male infertility. (c) 2009 Elsevier Inc. All rights reserved.