Analytic Comparison Between X-Ray Fluorescence CT and K-Edge CT
Analytic Comparison Between X-Ray Fluorescence CT and K-Edge CT
复制标题
X射线荧光CT与K边缘CT的分析比较
DOI：
10.1109/tbme.2013.2294677
复制
发表时间：
2014-03-01
影响因子：
4.6
通讯作者：
Wang, Ge
中科院分区：
文献类型：
--
作者：
Feng, Peng;Cong, Wenxiang;Wang, Ge
X 射线荧光计算机断层扫描 (XFCT) 和 K 边缘计算机断层扫描 (CT) 是临床前研究中量化小动物体内金纳米颗粒 (GNP) 分布的两种重要方法。确定哪种模式对于给定应用程序更有效是很有价值的。在本文中，我们报告了两种模式的信噪比（SNR）方面的理论分析，表明存在 GNP 浓度阈值，因此当 GNP 浓度小于该阈值时，XFCT 比 K 边缘 CT 具有更好的 SNR，反之亦然。对具有多种浓度水平和结构特征的两种体模进行了XFCT和K边缘CT的数值测试。实验结果表明，当造影剂浓度低于0.4%时，XFCT优于K边缘CT，这与理论分析相符。
X-ray fluorescence computed tomography (XFCT) and K-edge computed tomography (CT) are two important modalities to quantify a distribution of gold nanoparticles (GNPs) in a small animal for preclinical studies. It is valuable to determine which modality is more efficient for a given application. In this paper, we report a theoretical analysis in terms of signal-to-noise ratio (SNR) for the two modalities, showing that there is a threshold of GNPs concentration such that XFCT has a better SNR than K-edge CT when GNPs concentration is less than this threshold, vice versa. Numerical tests are performed for XFCT and K-edge CT on two kinds of phantoms with multiple concentration levels and structural features. Experimental results illustrate that XFCT is superior to K-edge CT when contrast concentration is lower than 0.4% which coincides with the theoretical analysis.