Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
复制标题
内侧颞叶癫痫伴海马硬化的海马亚区体积变化和记忆表现
DOI：
10.1007/s12264-017-0186-2
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发表时间：
2018-04-01
影响因子：
5.6
通讯作者：
Li, Hong
中科院分区：
文献类型：
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作者：
Ji, Caihong;Zhu, Lujia;Li, Hong
在本研究中，我们探讨了左侧和右侧内侧颞叶癫痫合并海马硬化症(TLE-HS)患者海马区体积萎缩的不同模式。同时，对汉语TLE-HS患者的记忆障碍模式及其可能的影响因素也进行了研究。对21例TLE-HS患者(左侧21例，右侧17例)和21例健康对照进行T2加权成像和言语/非言语记忆评估。结果显示，左侧和右侧TLE-HS患者硬化侧海马区体积总体缩小，而羊角区(CA1)萎缩程度最大。左侧TLE-HS患者的言语记忆明显受损(P<；0.001)，且与左侧海马区的体积无关。右侧TLE-HS患者未发现言语或非言语记忆障碍。这些结果提示，海马区体积的萎缩不能解释言语记忆的损害，这可能与功能网络有关。
In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Meanwhile, the memory impairment patterns in Chinese-speaking TLE-HS patients and potential influencing factors were also determined. TLE-HS patients (21 left and 17 right) and 21 healthy controls were recruited to complete T2-weighted imaging and verbal/nonverbal memory assessment. The results showed that both left and right TLE-HS patients had overall reduced hippocampal subregion volumes on the sclerotic side, and cornu ammonis sectors (CA1) exhibited maximum atrophy. The verbal memory of left TLE-HS patients was significantly impaired (P< 0.001) and was not associated with the volumes of the left hippocampal subregions. Verbal or nonverbal memory impairment was not found in the patients with right TLE-HS. These results suggested that the atrophy of hippocampal subregion volumes cannot account for the verbal memory impairment, which might be related to the functional network.