Outbreak of neurologic enterovirus type 71 disease:: A diagnostic challenge
Outbreak of neurologic enterovirus type 71 disease:: A diagnostic challenge
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DOI：
10.1086/521895
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发表时间：
2007-10-15
影响因子：
11.8
通讯作者：
Glode, Mary P.
中科院分区：
文献类型：
--
作者：
Perez-Velez, Carlos M.;Anderson, Marsha S.;Glode, Mary P.
背景与脊髓灰质炎病毒类似，肠道病毒71型（EV 71）可引起严重疾病，包括无菌性脑膜炎、脑炎、急性弛缓性麻痹和急性心肺功能障碍。EV 71感染的大流行已在世界范围内报道。在确认一组EV 71疾病病例后，我们回顾了2003年至2005年在科罗拉多丹佛儿童医院住院的EV 71疾病患者的记录。采用逆转录-聚合酶链反应（PCR）和/或病毒培养法检测肠道病毒，基因测序鉴定为EV 71型。2003年和2005年共发现8例EV 71病例。五十六%的EV 71型疾病患者
Background. Similar to poliovirus, enterovirus type 71 (EV71) causes severe disease, including aseptic meningitis, encephalitis, acute flaccid paralysis, and acute cardiopulmonary dysfunction. Large epidemics of EV71 infection have been reported worldwide.Methods. After recognition of a cluster of cases of EV71 disease, we reviewed records of patients with EV71 disease who required hospitalization at The Children's Hospital in Denver, Colorado, from 2003 through 2005. The presence of enterovirus was detected by reverse-transcriptase polymerase chain reaction (PCR) and/or viral culture of specimens from multiple sources, and the virus was typed as EV71 using genetic sequencing.Results. Eight cases of EV71 disease were identified in both 2003 and 2005. Fifty-six percent of patients with EV71 disease were