Laser-induced experimental vascular occlusion using liposome-encapsulated ADP.
Laser-induced experimental vascular occlusion using liposome-encapsulated ADP.
复制标题
使用脂质体封装的 ADP 激光诱导实验性血管闭塞。
DOI：
10.1002/lsm.1900120607
复制
发表时间：
1992
影响因子：
2.4
通讯作者：
Moshfeghi,D
中科院分区：
文献类型：
--
作者：
Khoobehi,B;Peyman,GA;Bhatt,N;Moshfeghi,D
视网膜血管的治疗性阻塞通常有助于治疗各种病理状况。我们比较了氩激光光凝和温度敏感脂质体释放的二磷酸腺苷（ADP）与单独氩激光光凝对有色大鼠视网膜血管阻塞的联合作用。A组，8只眼用脂质体包裹的ADP和激光光凝治疗。B组8眼，单纯激光光凝治疗。两组的激光参数（功率、光斑大小、曝光时间）保持在相同水平。激光聚焦在视神经乳头处的视网膜血管上。A组8只眼中有6只在0时完全闭塞，以80 mW治疗效果最好。B组8只眼中只有1只达到完全闭塞。3个月后，A组8只眼中有4只保持完全闭塞，B组无眼闭塞。使用ADP和比单独使用传统激光光凝更低功率密度的激光光凝可以实现视网膜血管的完全和永久性阻塞。© 1992 Wiley利斯公司
The therapeutic occlusion of retinal vessels is often helpful in treating various pathological conditions. We compared the combined effects of argon laser photocoagulation and adenosine diphosphate (ADP) released from temperature‐sensitive liposomes with argon laser photocoagulation alone on occlusion of retinal vessels in pigmented rats.In Group A, 8 eyes were treated with liposome‐encapsulated ADP and laser photocoagulation. In Group B, 8 eyes were treated with laser photocoagulation alone. The laser parameters (power, spot size, exposure time) were maintained at the same levels for both groups. The laser was focused on the retinal vessels at the optic nerve head. The treated retinal vessels were observed at time zero, day 1, day 4, and weekly for a period of 3 months.At time zero, 6 of 8 eyes were totally occluded in Group A, with best results obtained at 80 mW. Only 1 of 8 eyes in Group B achieved total occlusion. After 3 months, 4 of 8 eyes in Group A remained totally occluded; no eyes in Group B were occluded. Complete and permanent occlusion of retinal vessels can be achieved by using ADP and laser photocoagulation of lower power density than traditional laser photocoagulation alone. © 1992 Wiley‐Liss, Inc.