Emerging roles of Nrf2 signal in non-small cell lung cancer.
Emerging roles of Nrf2 signal in non-small cell lung cancer.
复制标题
Nrf2 信号在非小细胞肺癌中的新作用
DOI：
10.1186/s13045-016-0246-5
复制
发表时间：
2016-02-27
影响因子：
28.5
通讯作者：
Wu K
中科院分区：
文献类型：
--
作者：
Tian Y;Liu Q;He X;Yuan X;Chen Y;Chu Q;Wu K
非小细胞肺癌（NSCLC）是世界上死亡率最高的肿瘤之一。由于分子生物学的进步，肺腺癌的治疗方法发生了革命性的变化，而肺鳞癌的治疗方法仍不令人满意。近年来研究发现，Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-like factor 2（Keap 1/Nrf 2）通路在肺癌组织中发生了高频率的改变，引起了研究者的关注。在非小细胞肺癌患者中，Nrf 2信号失调被认为是DNA和蛋白质水平上的共同特征。Nrf 2和其他途径之间的新兴关联已经得到阐明。MicroRNA也参与了Nrf 2的调控。激活或拮抗Nrf 2的药物在临床前研究中显示出效果，反映了Nrf 2在肿瘤发生和发展过程中的不同作用。预后评估表明Nrf 2信号对NSCLC患者的生存有负面影响。考虑到Nrf 2信号在NSCLC中的重要性，未来需要进一步研究。
Non-small cell lung cancer (NSCLC) causes considerable mortality in the world. Owing to molecular biological progress, treatments in adenocarcinoma have evolved revolutionarily while those in squamous lung cancer remain unsatisfied. Recent studies revealed high-frequency alteration of Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-like factor 2 (Keap1/Nrf2) pathway within squamous lung cancer, attracting researchers to focus on this particular pathway. In NSCLC patients, deregulated Nrf2 signal is recognized as a common feature at both DNA and protein level. Emerging associations between Nrf2 and other pathways have been elucidated. MicroRNA was also implicated in the regulation of Nrf2. Agents activating or antagonizing Nrf2 showed an effect in preclinical researches, reflecting different effects of Nrf2 during tumor initiation and progression. Prognostic evaluation demonstrated a negative impact of Nrf2 signal on NSCLC patients’ survival. Considering the importance of Nrf2 signal in NSCLC, further studies are required in the future.