Differences in the immune-inflammatory profiles of unipolar and bipolar depression
Differences in the immune-inflammatory profiles of unipolar and bipolar depression
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DOI：
10.1016/j.jad.2019.10.037
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发表时间：
2020-02-01
影响因子：
6.6
通讯作者：
Maes, Michael
中科院分区：
文献类型：
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作者：
Brunoni, Andre R.;Supasitthumrong, Thitiporn;Maes, Michael
背景：重性抑郁症（MDD）和双相抑郁症（BD）都有增加的免疫炎症激活。然而，有不清楚的模式，外周免疫profiles.Methods之间的差异：我们研究了245 MDD和59 BD患者，招募在同一中心，谁是在一个急性抑郁发作的中度严重程度这样的差异。分层二元逻辑回归分析和广义线性模型用于比较各组之间的血浆生物标志物水平并预测二分分类。白细胞介素（IL）-1 β、肿瘤坏死因子（TNF）-α、可溶性TNF受体（sTNFR）1、IL-12和IL-10在MDD中显著高于BD，而IL-6、sTNFR 2、IL-18、IL-33、BD组ST 2（IL 1 R Like 1）和KLOTHO表达明显高于MDD组。此外，使用IL-6、IL-8、ST 2、sTNFR 2（与BD直接相关）和IL-12和TNF-α（与MDD直接相关）的组合，逻辑回归分析正确分类了BD和MDD患者，准确率为98.1%。伴有抑郁症状的MDD患者IL-1 β水平高于不伴有抑郁症状的患者。sTNFR 1/sTNFR 2比值显著预测抑郁症、状态和特质焦虑以及负性情感。结果仍然显着后协变量调整，包括药物使用。局限性：横断面研究。缺乏对照组。结论：BD和MDD患者之间存在免疫特征差异，特别是对于代偿性免疫调节系统（CIRS）：增加IL-10是MDD的主要免疫调节机制，而增加sTNFR 2和KLOTHO是BD的主要调节机制。
Background: Major depressive disorder (MDD) and bipolar depression (BD) both share increased immune-inflammatory activation. However, there are unclear patterns of differences in peripheral immune profiles between them.Methods: We examined such differences in 245 MDD and 59 BD patients, recruited in the same center, who were in an acute depressive episode of moderate severity. Hierarchical binary logistic regression analyses and generalized linear models were used to compare levels of plasma biomarkers between groups and to predict dichotomous classification.Results: Interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, soluble TNF receptor (sTNFR)1, IL-12 and IL-10 were significantly higher in MDD than in BD, whereas IL-6, sTNFR2, IL-18, IL-33, ST2 (IL1R Like 1) and KLOTHO were significantly higher in BD than in MDD. Moreover, logistic regression analyses correctly classified BD and MDD patients with 98.1% accuracy, using a combination of IL-6, IL-8, ST2, sTNFR2 (directly associated with BD) and IL-12 and TNF-alpha (directly associated with MDD). Patients with MDD with melancholic features showed higher IL-1 beta levels than those without melancholia. The sTNFR1 / sTNFR2 ratio significantly predicted MDD and state and trait anxiety and negative affect. Results remained significant after covariate adjustment, including drug use.Limitations: Cross-sectional study. Lack of control comparison group. Differences in exposure to medications among participants.Conclusions: Differences in immune profiles between BD and MDD patients exist, especially for the compensatory immune-regulatory system (CIRS): increased IL-10 is the primary immune-regulatory mechanism in MDD, while increased sTNFR2 and KLOTHO are the primary regulatory mechanisms in BD.