Prognostic significance of cyclin D1 and p16 in patients with intermediate-risk head and neck squamous cell carcinoma treated with docetaxel and concurrent radiotherapy
Prognostic significance of cyclin D1 and p16 in patients with intermediate-risk head and neck squamous cell carcinoma treated with docetaxel and concurrent radiotherapy
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DOI：
10.1002/hed.20632
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发表时间：
2007-10-01
影响因子：
2.9
通讯作者：
Fukuda, Satoshi
中科院分区：
文献类型：
--
作者：
Higuchl, Eisaku;Oridate, Nobuhiko;Fukuda, Satoshi
背景本研究旨在评价细胞周期调控蛋白cyclin D1和p16作为头颈部鳞状细胞癌（HNSCC）患者多西他赛联合放疗的预后标志物的意义。采用免疫组织化学方法对53例T1- 3 N 0 - 2 M0期（T1 NO声门除外）HNSCC患者进行回顾性研究，这些患者均接受多西他赛10 mg/m2/周治疗4 - 6次，并接受同步放化疗。Kaplan-Meier单变量分析显示，与cyclin D1阴性或p16阳性肿瘤患者相比，cyclin D1阳性或p16阴性肿瘤患者的预后更差（分别为p = 0.0004和p = 0.025）。使用比例风险回归模型证实了细胞周期蛋白D1表达而非p16表达的预后意义。评估细胞周期蛋白D1和p16的水平可能是临床上使用的定义亚组的患者预后不良。(c)2007 Wiley Periodicals，Inc.
Background. The current study aimed to evaluate the significance of the cell-cycle-control proteins cyclin D1 and p16 as prognostic markers in head and neck squamous cell carcinoma (HNSCC) patients treated with docetaxel and radiotherapy.Methods. Cyclin D1 and/or p16 protein expression was retrospectively evaluated by immunohistochemistry in 53 patients with stage T1-3N0-2M0 (except T1NO glottis) HNSCC who were treated with 10 mg/m(2)/week docetaxel 4 to 6 times and received concurrent chemoradiotherapy.Results. Kaplan-Meier univariate analysis revealed that patients with cyclin D1-positive tumors or p16-negative tumors had a worse prognosis compared with those with cyclin D1-negative tumors or p16-positive tumors (p =.0004 and p =.025, respectively). The prognostic significance of cyclin D1 expression, not p16 expression, was confirmed using a proportional hazard regression model.Conclusions. An assessment of cyclin D1 and p16 levels might be of clinical use in defining subgroups of patients with poor prognosis. (c) 2007 Wiley Periodicals, Inc.