The Emerging Role of PRMT6 in Cancer.
The Emerging Role of PRMT6 in Cancer.
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DOI：
10.3389/fonc.2022.841381
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发表时间：
2022
影响因子：
4.7
通讯作者：
Zhao H
中科院分区：
文献类型：
--
作者：
Chen Z;Gan J;Wei Z;Zhang M;Du Y;Xu C;Zhao H
蛋白质精氨酸甲基转移酶6（PRMT6）是一种I型PRMT，其通过甲基化组蛋白或非组蛋白蛋白参与基因表达的表观遗传调控，以及其他过程，如选择性剪接、DNA修复、细胞增殖和衰老以及细胞信号传导。此外，PRMT6还通过影响细胞生长、迁移、侵袭、凋亡和耐药性在多种癌症中发挥不同的作用，这使得PRMT6成为多种癌症的抗肿瘤治疗靶点。因此，许多PRMT6抑制剂被用于探索其作为各种癌症的潜在药物的功效。本文就PRMT6的结构和功能作一综述。与此同时，我们强调PRMT6在不同癌症中的作用，包括其促进或抑制作用的差异及其潜在机制。此外，本文还对PRMT6的研究进展及其可能的作用机制进行了综述。
Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that is involved in epigenetic regulation of gene expression through methylating histone or non-histone proteins, and other processes such as alternative splicing, DNA repair, cell proliferation and senescence, and cell signaling. In addition, PRMT6 also plays different roles in various cancers via influencing cell growth, migration, invasion, apoptosis, and drug resistant, which make PRMT6 an anti-tumor therapeutic target for a variety of cancers. As a result, many PRMT6 inhibitors are being utilized to explore their efficacy as potential drugs for various cancers. In this review, we summarize the current knowledge on the function and structure of PRMT6. At the same time, we highlight the role of PRMT6 in different cancers, including the differentiation of its promotive or inhibitory effects and the underlying mechanisms. Apart from the above, current research progress and the potential mechanisms of PRMT6 behind them were also summarized.
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影响因子：
6
作者：
Bryant JP;Heiss J;Banasavadi-Siddegowda YK
通讯作者：
Banasavadi-Siddegowda YK
DOI：
10.1200/jco.2014.60.0734
发表时间：
2015-07-10
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Bielack SS;Smeland S;Whelan JS;Marina N;Jovic G;Hook JM;Krailo MD;Gebhardt M;Pápai Z;Meyer J;Nadel H;Randall RL;Deffenbaugh C;Nagarajan R;Brennan B;Letson GD;Teot LA;Goorin A;Baumhoer D;Kager L;Werner M;Lau CC;Sundby Hall K;Gelderblom H;Meyers P;Gorlick R;Windhager R;Helmke K;Eriksson M;Hoogerbrugge PM;Schomberg P;Tunn PU;Kühne T;Jürgens H;van den Berg H;Böhling T;Picton S;Renard M;Reichardt P;Gerss J;Butterfass-Bahloul T;Morris C;Hogendoorn PC;Seddon B;Calaminus G;Michelagnoli M;Dhooge C;Sydes MR;Bernstein M;EURAMOS-1 investigators
通讯作者：
EURAMOS-1 investigators
影响因子：
8.8
作者：
Chiang K;Zielinska AE;Shaaban AM;Sanchez-Bailon MP;Jarrold J;Clarke TL;Zhang J;Francis A;Jones LJ;Smith S;Barbash O;Guccione E;Farnie G;Smalley MJ;Davies CC
通讯作者：
Davies CC
影响因子：
3.6
作者：
Chu, MC;Selam, FB;Taylor, HS
通讯作者：
Taylor, HS
影响因子：
8.8
作者：
Chan, Lok Hei;Zhou, Lei;Ma, Stephanie
通讯作者：
Ma, Stephanie