Ten years of highly active antiretroviral therapy for HIV infection
Ten years of highly active antiretroviral therapy for HIV infection
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DOI：
10.5694/j.1326-5377.2007.tb00839.x
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发表时间：
2007-02-05
影响因子：
11.4
通讯作者：
Lewin, Sharon R.
中科院分区：
文献类型：
--
作者：
Chen, Luke F.;Hoy, Jennifer;Lewin, Sharon R.
在过去的10年里，艾滋病毒感染的管理已经被越来越多的有效抗逆转录病毒药物（ARV）所改变，这些药物的剂量更方便，耐受性更好。艾滋病毒感染的最佳管理包括至少三种有效的ARV;至少两种不同的药物类别。目前的策略和药物可以有效地控制艾滋病毒，显著降低发病率和死亡率。然而，目前还没有治愈的可能。适当使用抗逆转录病毒药物可以抑制病毒的复制（低于使用商业测定来测量血浆中的HIV的检测限）和CD 4（+）T细胞的增加而几乎没有副作用。有效的病毒抑制和免疫改善需要大于95%的药物治疗依从性。药物间相互作用是常见的，在开具抑制或诱导细胞色素P450途径的抗逆转录病毒药物时需要谨慎。
Over the past 10 years, the management of HIV infection has been transformed by an increased number of effective antiretrovirals (ARVs), with more convenient dosing and improved tolerability.Optimal management of HIV infection includes at least three effective ARVs; from at least two different drug classes.Current strategies and drugs can effectively control HIV and significantly reduce morbidity and mortality. However, no cure is yet possible.Appropriate use of ARVs leads to suppression of virological replication (to below the limit of detection using commercial assays to measure HIV in plasma) and an increase in CD4(+) T cells with few adverse effects.Greater than 95% adherence to drug therapy is required for effective viral suppression and immunological improvement.Monotherapy, two-drug combinations, sequential ARVs, drug "cycling", and treatment interruptions are ineffective management strategies and lead to earlier disease progression and emergence of drug resistance.Drug-drug interactions are common and caution is required when prescribing ARVs that inhibit or induce the cytochrome P450 pathway.