Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus
Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus
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DOI：
10.1007/s00330-008-1044-4
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发表时间：
2008-11-01
影响因子：
5.9
通讯作者：
Mori, Etsuro
中科院分区：
文献类型：
--
作者：
Ishii, Kazunari;Kanda, Tomonori;Mori, Etsuro
探讨胼胝体角（CA）测量在特发性常压脑积水（INPH）诊断中的应用价值。对34例INPH患者、34例阿尔茨海默病（AD）患者和34例正常对照（NC）进行了三维磁共振成像（MRI）检查。所有受试者均在垂直于前后联合平面的后联合冠状MR图像上测量CA。INPH组的CA（平均+/- CeSD， 66 +/- 14度）明显小于AD（104 +/- 15度）和NC（112 +/- 11度）组。当使用NC组的均值- 2sd值阈值（= 90）时，区分INPH和AD患者的准确率为93%，灵敏度为97%，特异性为88%。测量CA有助于区分INPH患者与AD和正常年龄受试者。
The utility of measuring the corpus callosal angle (CA) for the diagnosis of idiopathic normal pressure hydrocephalus (INPH) was investigated. Three-dimensional magnetic resonance imaging (MRI) was performed in 34 INPH patients, 34 Alzheimer's disease (AD) patients, and 34 normal control (NC) subjects. Measurement of the CA on the coronal MR images of the posterior commissure perpendicular to the anteroposterior commissure plane was performed for all subjects. The CA of the INPH group (mean +/- CeSD, 66 +/- 14 degrees) was significantly smaller than those of the AD (104 +/- 15 degrees) and NC (112 +/- 11 degrees) groups. When using the threshold of the meane-2SD value of the NC group (= 90), an accuracy of 93%, sensitivity of 97%, and specificity of 88% were observed for discrimination of INPH from AD patients. Measuring the CA helps in differentiating INPH patients from AD and normally aged subjects.