The role of survivin for radiation therapy -: Prognostic and predictive factor and therapeutic target
The role of survivin for radiation therapy -: Prognostic and predictive factor and therapeutic target
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DOI：
10.1007/s00066-007-1800-4
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发表时间：
2007-11-01
影响因子：
3.1
通讯作者：
Roedel, Franz
中科院分区：
文献类型：
--
作者：
Capalbo, Gianni;Roedel, Claus;Roedel, Franz
背景资料：Survivin是凋亡抑制蛋白（IAP）家族中最小的成员，是一种具有双重功能的蛋白质，参与细胞分裂和凋亡的调控。材料与方法：本文综述了Survivin在放射肿瘤学中的相关性及其作为放射增敏肿瘤细胞的治疗靶点的临床和实验数据。与正常组织相比，生存素在肿瘤中过表达，并且似乎与肿瘤恶性程度和治疗反应密切相关。此外，生存素参与肿瘤细胞对化疗和电离辐射的抗性。由于这些特性，生存素已被提议作为抗癌疗法的有吸引力的靶点。一些临床前研究表明，抑制生存素，通过使用反义寡核苷酸，小干扰RNA，核酶和显性负突变体的应用，增加凋亡，减少肿瘤细胞的生存和降低肿瘤生长potential.Conclusion：生存素显示相关的预后和预测因子，以及一个有前途的分子靶点，以提高放射治疗的效果。
Background: Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is a bifunctional protein that has been implicated in both control of cell division and inhibition of apoptosis.Material and Methods: This review specially focuses on clinical and experimental data on the relevance of survivin in radiooncology and its role as a therapeutic target to radiosensitize tumor cells.Results: As compared to normal tissue, survivin is overexpressed in tumors and appears to be closely related to tumor malignancy and treatment response. In addition, survivin is involved in the resistance of tumor cells to both chemotherapy and ionising irradiation. Due to these properties, survivin has been proposed as an attractive target for anticancer therapies. Several preclinical studies have demonstrated that suppression of survivin, by the use of antisense oligonucleotides, small interfering RNAs, ribozymes and the application of dominant negative mutants, increases apoptotosis, diminishes tumor cell survival and reduces tumor growth potential.Conclusion: Survivin displays a relevant prognostic and predictive factor as well as a promising molecular target to improve the effectiveness of radiotherapy.