Maternal prenatal anxiety and corticotropin-releasing hormone associated with timing of delivery
Maternal prenatal anxiety and corticotropin-releasing hormone associated with timing of delivery
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DOI：
10.1097/01.psy.0000138284.70670.d5
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发表时间：
2004-09-01
影响因子：
3.3
通讯作者：
Hobel, CJ
中科院分区：
文献类型：
--
作者：
Mancuso, RA;Schetter, CD;Hobel, CJ
目的：在美国，高早产率是一个严重的公共卫生问题。过去的研究表明，产前压力、焦虑和母体血浆促肾上腺皮质激素再释放激素（CRH）水平升高与人类和动物的早产有关。迄今为止的研究还没有一起检查这三个变量；这就是本文的目的。方法：对282例孕妇资料进行分析，探讨产妇产前焦虑和CRH对妊娠期长短的影响。假设在妊娠18 ~ 20周（时间1）和28 ~ 30周（时间2），CRH和产妇产前焦虑与分娩胎龄呈负相关。CRH也被期望调解产妇产前焦虑和分娩胎龄的关系。结果：研究结果支持Time 2的中介假设，表明妊娠28 ~ 30周CRH水平高且母体产前焦虑高的女性比CRH水平低且母体产前焦虑高的女性分娩早。早产妇女在妊娠18 ~ 20周和妊娠28 ~ 30周的CRH发生率均显著增高
Objective: The high rate of preterm births is an imposing public health issue in the United States. Past research has suggested that prenatal stress, anxiety, and elevated levels of maternal plasma corticotropin-re leasing hormone (CRH) are associated with preterm delivery in humans and animals. Studies to date have not examined all three variables together; that is the objective of this paper. Methods: Data from 282 pregnant women were analyzed to investigate the effect of maternal prenatal anxiety and CRH on the length of gestation. It was hypothesized that at both 18 to 20 weeks (Time 1) and 28 to 30 weeks gestation (Time 2), CRH and maternal prenatal anxiety would be negatively associated with gestational age at delivery. CRH was also expected to mediate the relationship between maternal prenatal anxiety and gestational age at delivery. Results: Findings supported the mediation hypothesis at Time 2, indicating that women with high CRH levels and high maternal prenatal anxiety at 28 to 30 weeks gestation delivered earlier than women with lower CRH levels and maternal prenatal anxiety. Women who delivered preterm had significantly higher rates of CRH at both 18 to 20 weeks gestation and 28 to 30 weeks gestation (p