Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens
Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens
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DOI：
10.1016/j.sbi.2012.02.001
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发表时间：
2012-08-01
影响因子：
6.8
通讯作者：
Waksman, Gabriel
中科院分区：
文献类型：
--
作者：
Allen, William J.;Phan, Gilles;Waksman, Gabriel
皮利属于细菌表面结构的大类，在感染和致病性中起关键作用。最大和最具特色的菌毛生物发生系统-伴侣引导途径-特别引人注目的是，它能够在没有任何内源性能量来源输入的情况下在外膜合成和显示高度组织化的结构。在过去的几年里，我们对菌毛组装的结构生物学和机制的理解取得了令人兴奋的新进展，本文对此进行了讨论。这些知识在未来将特别重要，因为我们即将进入一个对常见抗生素普遍耐药的时代，需要新的靶标。
Pili belong to a broad class of bacterial surface structures that play a key role in infection and pathogenicity. The largest and best characterised pilus biogenesis system - the chaperoneusher pathway - is particularly remarkable in its ability to synthesise and display highly organised structures at the outer membrane without any input from endogenous energy sources. The past few years have heralded exciting new developments in our understanding of the structural biology and mechanism of pilus assembly, which are discussed in this review. Such knowledge will be particularly important in the future, as we approach an era of widespread resistance to common antibiotics and require new targets.