The evolution of the antimicrobial peptide database over 18 years: Milestones and new features.
The evolution of the antimicrobial peptide database over 18 years: Milestones and new features.
复制标题
抗菌肽数据库 18 年来的演变：里程碑和新功能。
DOI：
10.1002/pro.4185
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Wang,Zhe
中科院分区：
文献类型：
--
作者：
Wang,Guangshun;Zietz,CMichael;Mudgapalli,Ashok;Wang,Shuona;Wang,Zhe
抗菌肽数据库（APD）已服务抗菌肽领域18年。由于它广泛用于研究和教育，本文记录了数据库的里程碑和关键事件，使其转变为当前的形式。对2010年至2020年的APD肽统计数据进行了比较，验证了迄今为止的主要数据库发现。我们还描述了新增加的范围从肽条目的搜索功能。值得注意的是，APD还含有来自宿主微生物群的抗菌肽，这些抗菌肽在塑造免疫系统方面很重要，可能与多种人类疾病有关。最后，数据库已重新编程为内布拉斯加大学医学中心的网络品牌和最新的安全合规性。重新编程的APD可在https://aps.unmc.edu上访问。
The antimicrobial peptide database (APD) has served the antimicrobial peptide field for 18 years. Because it is widely used in research and education, this article documents database milestones and key events that have transformed it into the current form. A comparison is made for the APD peptide statistics between 2010 and 2020, validating the major database findings to date. We also describe new additions ranging from peptide entries to search functions. Of note, the APD also contains antimicrobial peptides from host microbiota, which are important in shaping immune systems and could be linked to a variety of human diseases. Finally, the database has been re‐programmed to the web branding and latest security compliance of the University of Nebraska Medical Center. The reprogrammed APD can be accessed at https://aps.unmc.edu.