The role of Myc-induced protein synthesis in cancer.
The role of Myc-induced protein synthesis in cancer.
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DOI：
10.1158/0008-5472.can-09-1970
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发表时间：
2009-12-01
期刊：
影响因子：
11.2
通讯作者：
Ruggero D
中科院分区：
文献类型：
--
作者：
Ruggero D
翻译控制的不同步骤中的失调是癌症形成的一种新兴机制。在翻译控制中具有直接作用的癌基因的一个实例是Myc转录因子。Myc通过控制蛋白质合成机制的多个组分的表达来直接增加蛋白质合成速率，所述组分包括核糖体蛋白、翻译起始因子、Pol III和rDNA。然而，Myc依赖性蛋白质合成增加对导致癌症的多步骤过程的贡献仍然未知。最近的证据有力地表明，Myc致癌信号可能垄断的翻译机制，引起细胞生长，细胞周期的进展，和基因组不稳定性的协同作用，作为一种机制，癌症的起始。此外，新的遗传工具，以恢复异常增加的蛋白质合成控制，这应该能够解剖的重要机制，癌症依赖于翻译机制。
Deregulation in different steps of translational control is an emerging mechanism for cancer formation. One example of an oncogene with a direct role in control of translation is the Myc transcription factor. Myc directly increases protein synthesis rates by controlling the expression of multiple components of the protein synthetic machinery, including ribosomal proteins, initiation factors of translation, Pol III and rDNA. However, the contribution of Myc-dependent increases in protein synthesis towards the multi-step process leading to cancer has remained unknown. Recent evidence strongly suggests that Myc oncogenic signaling may monopolize the translational machinery to elicit cooperative effects on cell growth, cell cycle progression, and genome instability as a mechanism for cancer initiation. Moreover, new genetic tools to restore aberrant increases in protein synthesis control are now available, which should enable the dissection of important mechanisms in cancer that rely on the translational machinery.