FIZZ1 Plays a Crucial Role in Early Stage Airway Remodeling of OVA-Induced Asthma
FIZZ1 Plays a Crucial Role in Early Stage Airway Remodeling of OVA-Induced Asthma
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DOI：
10.1080/02770900802126941
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发表时间：
2008-01-01
影响因子：
1.9
通讯作者：
Bi, Wen-Xiang
中科院分区：
文献类型：
--
作者：
Dong, Liang;Wang, Shu-Juan;Bi, Wen-Xiang
本研究的目的是阐明炎症区1（FIZZ 1，也称为AM-alpha或抵抗素样分子-alpha）在哮喘气道重塑中的作用。我们使用卵清蛋白（OVA）致敏和激发的大鼠模型来诱导肺炎症和重塑。与对照盐水处理的动物相比，OVA处理的大鼠肺中的α-SMA表达在支气管周围区域显著升高。FIZZ 1 mRNA的表达在肺泡上皮II型细胞（AECII）从OVA处理的动物分离高于对照组动物。与对照转染细胞相比，在大鼠-1肺成纤维细胞系中强制表达重组FIZZ 1增强了I型胶原和α-SMA的产生。这些结果表明，FIZZ 1可以诱导成纤维细胞表达肌成纤维细胞分化的标志物，如α-SMA和I型胶原蛋白，这是哮喘气道重塑早期阶段的特征。
The aim of this study was to elucidate the role of Found in Inflammatory Zone 1 (FIZZ1, also known as RELM-alpha or resistin-like molecule-alpha) in airway remodeling in asthma. We used a rat model of ovalbumin (OVA) sensitization and challenge to induce lung inflammation and remodeling. Expression of alpha-SMA in the lungs of OVA-treated rats was significantly elevated in the peribronchial regions compared with control saline-treated animals. Expression of FIZZ1 mRNA in alveolar epithelial type II cells (AECII) isolated from OVA-treated animals was higher than in control animals. Forced expression of recombinant FIZZ1 in rat-1 lung fibroblast cell line enhanced production of collagen type I and alpha-SMA compared with control transfected cells. These results suggest that FIZZ1 can induce fibroblasts to express markers of myofibroblast differentiation such as alpha-SMA and collagen type I, which are characteristic of early stages of airway remodeling seen in asthma.