From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.
From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.
复制标题
从古代途径到衰老细胞——连接新陈代谢和细胞衰老。
DOI：
10.1016/j.cmet.2016.05.010
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发表时间：
2016-06-14
期刊：
影响因子：
29
通讯作者：
Campisi J
中科院分区：
文献类型：
--
作者：
Wiley CD;Campisi J
细胞衰老是一种复杂的应激反应，它永久性地阻止了有致癌转化风险的细胞的增殖。然而，衰老细胞也可以驱动与衰老相关的表型。尽管衰老相关的生长停滞可以预防癌症的发生，并且癌细胞的代谢已得到深入研究，但直到最近，细胞衰老的代谢原因和后果在很大程度上尚未得到探索。新的发现揭示了细胞代谢的几个方面在衰老表型的建立和控制中的关键作用。这些发现对癌症和衰老都有重要意义。在这篇综述中，我们强调了一些最近的代谢和表型之间的联系，通常与衰老细胞。
Cellular senescence is a complex stress response that permanently arrests the proliferation of cells at risk for oncogenic transformation. However, senescent cells can also drive phenotypes associated with aging. Although the senescence-associated growth arrest prevents the development of cancer and the metabolism of cancer cells has been studied in depth, the metabolic causes and consequences of cellular senescence were largely unexplored until recently. New findings reveal key roles for several aspects of cellular metabolism in the establishment and control of senescent phenotypes. These discoveries have important implications for both cancer and aging. In this review, we highlight some of the recent links between metabolism and phenotypes that are commonly associated with senescent cells.