Common alterations in the serotonin transporter in platelets and lymphocytes of psychotic patients
Common alterations in the serotonin transporter in platelets and lymphocytes of psychotic patients
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DOI：
10.1055/s-2006-931477
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发表时间：
2006-01-01
影响因子：
4.3
通讯作者：
Cassano, GB
中科院分区：
文献类型：
--
作者：
Marazziti, D;Dell'Osso, B;Cassano, GB
简介：鉴于有关血清素 (5-HT) 转运蛋白在精神病中的作用的争议数据，我们的研究旨在通过测量 25 名不同精神病患者的血小板和淋巴细胞的再摄取动力学和蛋白质密度来研究这种结构。方法：根据 DSM-IV 标准，诊断为具有情绪不一致精神病特征的双相 1 型障碍 (14)、混合状态 (7) 和精神分裂症 (4)。还选择25名匹配的健康受试者作为对照组。根据标准化方案制备血小板和淋巴细胞膜，[H-3]5HT 再摄取和[H-3]帕罗西汀 ([H-3]Par) 结合也是如此。结果：本研究结果显示，与健康对照受试者相比，精神病患者血小板和淋巴细胞中 ['H]Par 结合位点密度降低，同时 [H-3]5-HT 再摄取速度降低。结论：这些发现表明精神病患者 5-HT 系统普遍存在异常，可能不仅仅局限于大脑。
Introduction: Given the controversial data concerning the role of the serotonin (5-HT) transporter in psychosis, our study was aimed to investigate this structure by means of the measurements of the re-uptake kinetics and of the protein density, in both platelets and lymphocytes of 25 out- and inpatients with different psychotic disorders. Methods: Diagnoses, according to DSM-IV criteria, were bipolar 1 disorders with mood incongruent psychotic features (14), mixed states (7) and schizophrenia (4). Twenty-five matched healthy subjects were also selected as the control group. Platelet and lymphocyte membranes were prepared according to standardized protocols, as were the [H-3]5HT re-uptake and [H-3]paroxetine ([H-3]Par) binding. Results: The results of this study showed a decreased density of the ['H]Par binding sites coupled with a reduced velocity of [H-3]5-HT re-uptake in both platelets and lymphocytes of psychotic patients, as compared with healthy control subjects. Conclusion: These findings would suggest a general abnormality of the 5-HT system in psychotic patients, probably not confined only to the brain.