Fatty acid transport proteins, implications in physiology and disease.
Fatty acid transport proteins, implications in physiology and disease.
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DOI：
10.1016/j.bbalip.2011.09.010
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Stahl A
中科院分区：
文献类型：
--
作者：
Kazantzis M;Stahl A
长链脂肪酸的摄取在代谢稳态和人体生理学中起着关键作用。必须以特定器官的方式控制摄取率，以在禁食和进食状态之间的过渡期间平衡储存与代谢需求。许多与肥胖相关的疾病，如骨骼肌胰岛素抵抗、心脏脂肪毒性和肝脏脂肪变性，被认为是由脂肪储存中脂肪酸溢出以及随后脂质异位积累导致细胞凋亡、内质网应激和胰岛素受体信号级联失活引起的。因此，了解调节不同器官系统之间脂肪酸流动的成分至关重要。关键代谢器官（包括肠道、脂肪组织、肌肉、心脏和肝脏）对脂肪酸的细胞摄取已被证明是蛋白质介导的，并且所有这些组织都表达脂肪酸转运蛋白 (FATP/SLC27A1-6) 的各种独特组合。在这里，我们回顾了目前对 FATP 如何促进正常生理学以及 FATP 突变以及低形态和高形态变化如何导致从心脏脂肪毒性到肝脂肪变性和鱼鳞病等疾病的理解。最终，我们对 FATP 生物学知识的不断增长有可能为一些最普遍的人类慢性疾病开发新的诊断工具和治疗方案。
Uptake of long-chain fatty acids plays pivotal roles in metabolic homeostasis and human physiology. Uptake rates must be controlled in an organ-specific fashion to balance storage with metabolic needs during transitions between fasted and fed states. Many obesity-associated diseases, such as insulin resistance in skeletal muscle, cardiac lipotoxicity, and hepatic steatosis, are thought to be driven by the overflow of fatty acids from adipose stores and the subsequent ectopic accumulation of lipids resulting in apoptosis, ER stress, and inactivation of the insulin receptor signaling cascade. Thus, it is of critical importance to understand the components that regulate the flux of fatty acid between the different organ systems. Cellular uptake of fatty acids by key metabolic organs, including the intestine, adipose tissue, muscle, heart, and liver, has been shown to be protein mediated and various unique combinations of fatty acid transport proteins (FATPs/SLC27A1-6) are expressed by all of these tissues. Here we review our current understanding of how FATPs can contribute to normal physiology and how FATP mutations as well as hypo- and hypermorphic changes contribute to disorders ranging from cardiac lipotoxicity to hepatosteatosis and ichthyosis. Ultimately, our increasing knowledge of FATP biology has the potential to lead to the development of new diagnostic tools and treatment options for some of the most pervasive chronic human disorders.
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DOI：
10.1083/jcb.200207080
发表时间：
2003-06-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Herrmann T;van der Hoeven F;Grone HJ;Stewart AF;Langbein L;Kaiser I;Liebisch G;Gosch I;Buchkremer F;Drobnik W;Schmitz G;Stremmel W
通讯作者：
Stremmel W
影响因子：
2.2
作者：
Auinger, A.;Valenti, L.;Rubin, D.
通讯作者：
Rubin, D.
影响因子：
64.8
作者：
Hagberg, Carolina E.;Falkevall, Annelie;Eriksson, Ulf
通讯作者：
Eriksson, Ulf
影响因子：
4.8
作者：
Gimeno, RE;Hirsch, DJ;Stahl, A
通讯作者：
Stahl, A
DOI：
10.1073/pnas.95.15.8625
发表时间：
1998-07-21
影响因子：
11.1
作者：
Hirsch, D;Stahl, A;Lodish, HF
通讯作者：
Lodish, HF