Birth weight and the incidence of childhood cancer.
Birth weight and the incidence of childhood cancer.
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出生体重和儿童癌症的发病率。
DOI：
10.1093/jnci/72.5.1039
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
N. Weiss
中科院分区：
文献类型：
--
作者：
J. Daling;J. Daling;P. Starzyk;A. Olshan;N. Weiss;N. Weiss
研究了出生时体重与儿童癌症发生的关系，重点是诊断时年龄的影响。在华盛顿州出生的681名癌症儿童的出生证明与癌症登记数据相关联。在出生后头几年被诊断患有癌症的儿童中，出生体重偏高（超过4 000克）的比例有所增加。这种关系在2岁以下的儿童中最强;其中约有两倍的儿童出生时体重偏高。然而，这种关系在那些在4岁或以上被诊断出癌症的人中根本不存在。与高出生体重相关的幼儿的这种过度风险分布在几种癌症中，包括两种最常见的癌症（白血病和神经母细胞瘤）。
The relationship of weight at birth to the occurrence of childhood cancer was studied with emphasis on the influence of age at diagnosis. Birth certificates for 681 children with cancer born in Washington State were linked with cancer registry data. Among children diagnosed with cancer during the first several years of life, there was an increased proportion with a high birth weight (greater than 4,000 g). The relationship was strongest for children under 2 years of age; about twice as many of them had high birth weights. However, the relationship was not present at all in those whose cancer was diagnosed at age 4 or older. This excess risk in young children associated with high birth weight was distributed among several types of cancer, including the two most common ones (leukemia and neuroblastoma).