VISUAL DYSFUNCTION PREDICTS COGNITIVE DEFICITS IN ALZHEIMERS-DISEASE
VISUAL DYSFUNCTION PREDICTS COGNITIVE DEFICITS IN ALZHEIMERS-DISEASE
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DOI：
10.1097/00006324-199503000-00004
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发表时间：
1995-03-01
影响因子：
1.4
通讯作者：
GROWDON, JH
中科院分区：
文献类型：
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作者：
CRONINGOLOMB, A;CORKIN, S;GROWDON, JH
阿尔茨海默病（AD）患者普遍存在基本视觉能力的缺陷，这引发了其对认知功能影响的问题。 我们研究了72例AD患者的视觉和认知之间的关系。 视力测试评估了颜色辨别力、立体视敏度、对比敏感度和后向模式掩蔽。 对于物体识别的认知测试，至少25%（高达50%）的分数方差是由视觉测试的表现预测的。 对于空间定位测试，只有2%至11%的方差是由视觉测试的表现预测的。 结果表明：（1）视觉功能障碍是AD患者认知功能障碍的重要预测因素;（2）AD患者的视觉缺陷可能对特定认知领域的表现产生强烈的功能影响。
Deficits in basic visual capacities are prevalent in Alzheimer's disease (AD), raising the question of their impact on cognitive function. We examined the relation between vision and cognition in 72 patients with AD. Vision tests assessed color discrimination, stereoacuity, contrast sensitivity, and backward pattern masking. For cognitive tests of object recognition, at least 25% (up to 50%) of score variance was predicted by performance on a vision test. For tests of spatial localization, only 2 to 11% of the variance was predicted by performance on a vision test. The results indicated that: (1) visual dysfunction was a significant predictor of cognitive dysfunction in AD, and (2) visual deficits in AD may have a strong functional impact on performance in specific cognitive domains.