An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF₂CO₂Et at ambient temperature.
An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF₂CO₂Et at ambient temperature.
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DOI：
10.1039/c4cc04591b
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发表时间：
2014-07
影响因子：
4.9
通讯作者：
Guobin Ma;W. Wan;Jialiang Li;Qingyan Hu;Haizhen Jiang;Shizheng Zhu;Jing Wang;J. Hao
中科院分区：
文献类型：
--
作者：
Guobin Ma;W. Wan;Jialiang Li;Qingyan Hu;Haizhen Jiang;Shizheng Zhu;Jing Wang;J. Hao
发展了一种温和、通用、高效的未活化烯烃区域选择性氢二氟甲基化反应方法。这种Ag介导的Csp（3）-CF2键形成反应提供了容易获得各种邻位含α-二氟乙酸酯的烷烃的途径。
A mild, versatile and efficient method for the regioselective hydrodifluoromethylation of unactivated alkenes has been developed. This Ag-mediated Csp(3)-CF2 bond forming reaction provides easy access to a variety of vicinal α-difluoroacetate-containing alkanes.