Fecal excretions of hydroxy fatty acid and bile acid in diabetic diarrheal patients
Fecal excretions of hydroxy fatty acid and bile acid in diabetic diarrheal patients
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DOI：
10.1016/1056-8727(93)90017-s
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发表时间：
1993-01-01
影响因子：
3
通讯作者：
Takebe, Kazuo
中科院分区：
文献类型：
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作者：
Nakamura, Teruo;Imamura, Ken-Ichi;Takebe, Kazuo
对13例正常人、5例糖尿病对照组（I组）、13例无周围神经病变的糖尿病患者（II组）和7例糖尿病患者（III组）粪便中胆汁酸和羟基脂肪酸的排泄情况进行了比较。正常对照组每日粪便胆汁酸排泄量为304.9 mg，第Ⅰ组为297.8 mg，第Ⅱ组为382.4 mg，第Ⅲ组为958.2 mg，显著高于前三组（P <0.01），是对照组的近3倍。至于粪便脂肪酸排泄量，各组之间没有观察到显著差异。正常人（1.5%）、I组（2.0%）和II组（1.2%）的粪便羟基脂肪酸百分比无显著差异。与此相反，组III的羟基脂肪酸百分比大大增加（p lt 0.01）（13.2%）。从以上结果可以看出，糖尿病患者体内羟基脂肪酸的比例较高，提示存在细菌过度生长。同时，粪便胆汁酸水平增加约3倍，表明胆汁酸吸收从轻度到中度差。因此，认为粪便羟基脂肪酸和胆汁酸不太可能是糖尿病腹泻的原因。
Thirteen normal subjects, 5 diarrheal controls (Group I) and 13 diabetics without peripheral neuropathy (Group II) were compared with 7 diabetic patients (Group III) with respect to fecal excretions of bile acids and hydroxy fatty acids for pathogenesis of diabetic diarrhea. The mean fecal excretions of bile acids per day were 304.9 mg for the normal controls, 297.8 mg for Group I, and 382.4 mg for Group II, while those of Group III were significantly higher (958.2 mg, p lt 0.01) than the foregoing groups, and nearly three times as much as the controls. As to the fecal fatty acid excretion, there were no significant differences observed among these groups. The percentages of fecal hydroxy fatty acids were no significantly different in normal subjects (1.5%), Group I (2.0%), and Group II (1.2%). In contrast, the percentage of hydroxy fatty acid for Group III was greatly (p lt 0.01) increased (13.2%). From the above results, the percentage of hydroxy fatty acid in diabetic diarrheal patients was high, suggesting that there is bacterial overgrowth. Meanwhile, the fecal bile acid level was increased about three times, indicative of poor absorption of bile acid from mild to moderate degree. Therefore, it is considered improbable that fecal hydroxy fatty acids and bile acids are the cause of diabetic diarrhea.