A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
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DOI：
10.1039/b600382f
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发表时间：
2006-01-01
影响因子：
4.9
通讯作者：
Tranmer, Geoffrey K.
中科院分区：
文献类型：
--
作者：
Baxendale, Ian R.;Deeley, Jon;Tranmer, Geoffrey K.
描述了用于生物碱天然产物（+/-）-oxomaritidine的多步合成的流程，通过使用微流体泵送系统介导，该微流体泵送系统使材料通过含有固定化试剂、催化剂、清除剂或捕获和释放剂的各种填充柱;我们的路线涉及利用流动化学将七个独立的合成步骤连接成一个连续序列的组合。
A flow process for the multi-step synthesis of the alkaloid natural product (+/-)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.