Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function
Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function
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DOI：
10.1016/j.jid.2019.06.137
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发表时间：
2020-02-01
影响因子：
6.5
通讯作者：
Wickstrom, Sara A.
中科院分区：
文献类型：
--
作者：
Biggs, Leah C.;Kim, Christine S.;Wickstrom, Sara A.
组织形状来自个体细胞的集体机械特性和行为以及它们整合到周围组织中的方式。组织结构及其动态变化随后反馈指导细胞行为。皮肤是一个动态的、自我更新的屏障，在其整个生命周期中受到大规模的外部机械力。承受这种恒定的机械应力而不损害其作为屏障的完整性的能力需要隔室特定的结构专业化以及感知和适应机械提示的能力。这篇综述讨论了皮肤独特的机械特性和细胞与环境之间机械通讯产生的信号的重要性。
Tissue shape emerges from the collective mechanical properties and behavior of individual cells and the ways by which they integrate into the surrounding tissue. Tissue architecture and its dynamic changes subsequently feed back to guide cell behavior. The skin is a dynamic, self-renewing barrier that is subjected to large-scale extrinsic mechanical forces throughout its lifetime. The ability to withstand this constant mechanical stress without compromising its integrity as a barrier requires compartment-specific structural specialization and the capability to sense and adapt to mechanical cues. This review discusses the unique mechanical properties of the skin and the importance of signals that arise from mechanical communication between cells and their environment.