Synthesis and physicochemical analysis of interpenetrating networks containing modified gelatin and poly(ethylene glycol) diacrylate
Synthesis and physicochemical analysis of interpenetrating networks containing modified gelatin and poly(ethylene glycol) diacrylate
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DOI：
10.1002/jbm.a.10106
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发表时间：
2003-10-01
影响因子：
4.9
通讯作者：
Kao, WJ
中科院分区：
文献类型：
--
作者：
Burmania, JA;Martinez-Diaz, GJ;Kao, WJ
研究了明胶的改性、含量和聚乙二醇的相对分子质量对明胶与聚乙二醇二丙烯酸酯互穿网络(IPN)体系的熔融温度、表面亲水性、拉伸性能、溶胀/降解和药物释放动力学的影响。明胶含量对IPN的熔融温度和DeltaH有较大影响。用乙二胺四乙酸和/或单甲氧基聚乙二醇单乙酸酯修饰明胶，并增加聚乙二醇二丙烯酸酯的相对分子质量，提高了明胶的表面亲水性。增加明胶质量分数可提高IPN的室温弹性。当测试环境中存在缓冲和高温时，所有测试的IPN的弹性都下降。与戊二醛固定的明胶水凝胶相比，IPN显示出更强的弹性和强度。增加明胶含量或对明胶进行改性可提高IPN的溶胀和降解程度。与以戊二醛为交联剂的明胶相比，IPNS样品降解完成的时间更长。对IPN系统的改进增加了IPN中二葡萄糖酸氯己定的最大释放百分比。IPNS的药物完全释放速率慢于戊二醛固定的明胶骨架。通过配方的改变和化学修饰，获得了广泛的IPN物化性能。(C)2003年威利期刊公司。
The interrelated effects of gelatin modification, content, and poly(ethylene glycol) molecular weight on the melting temperature, surface hydrophilicity, tensile properties, swelling/degradation, and drug-release kinetics of a novel interpenetrating network (IPN) system containing gelatin and poly(ethylene glycol) diacrylate were evaluated. Gelatin content had a large effect on the IPN melting temperature and DeltaH. Modifying gelatin with ethylenediaminetetraacetic acid and/or monomethoxy poly(ethylene glycol) monoacetate ester as well as increasing poly(ethylene glycol) diacrylate molecular weight increased the surface hydrophilicity. Increasing the gelatin weight percent increased the IPN elasticity at room temperature. When buffer and elevated temperature were present in the testing environment, the elasticity of all IPNs tested decreased. IPNs showed an enhanced elasticity and strength when compared with glutaraldehyde-fixed gelatin hydrogels. The extent of IPN swelling and degradation was increased by increasing the gelatin content or by modifying gelatin. The time to complete sample degradation was longer for IPNs when compared with gelatin crosslinked with glutaraldehyde. Modifications to the IPN system increased the maximum percent of chlorhexidine digluconate released from the IPNs. The rate of complete drug release was slower from IPNs than from glutaraldehyde-fixed gelatin matrices. A wide range of IPN physicochemical properties was obtained through formulation changes and chemical modifications. (C) 2003 Wiley Periodicals, Inc.