The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo.
The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo.
复制标题
体内调节哺乳动物原始卵泡激活的因素和途径。
DOI：
10.3389/fcell.2020.575706
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Huang D
中科院分区：
文献类型：
--
作者：
Chen Y;Yang W;Shi X;Zhang C;Song G;Huang D
哺乳动物卵巢由作为基本功能单位的卵泡组成。每个卵泡由最里面的一个卵母细胞和周围几个扁平的颗粒细胞组成。与雄性不同的是，根据原始卵泡池的初始大小及其激活和耗尽的速度，雌性的生殖寿命在生命早期就被决定了。原始卵泡一旦被激活，就会进入不可逆转的发育过程。大多数卵泡经历闭锁变性，只有少数卵泡能够成熟和排卵。虽然已经有很多研究为探索原始卵泡的激活做出了贡献，但对其潜在的机制还知之甚少。因此，本文就近年来有关原始卵泡激活的信号转导途径及相关因素进行综述，以期对原始卵泡激活的细胞和分子机制有更深入的了解。
Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an innermost oocyte and several surrounding flattened granulosa cells. Unlike males, according to the initial size of the primordial follicle pool and the rate of its activation and depletion, a female’s reproductive life has been determined early in life. Primordial follicles, once activated, will get into an irreversible process of development. Most follicles undergo atretic degeneration, and only a few of them could mature and ovulate. Although there are a lot of researches contributing to exploring the activation of primordial follicles, little is known about its underlying mechanisms. Thus, in this review, we collected the latest papers and summarized the signaling pathways as well as some factors involved in the activation of primordial follicles, hoping to lead to a more profound understanding of the cellular and molecular mechanisms of primordial follicle activation.
影响因子：
1.5
作者：
Suzuki, Hitomi;Dann, Christina Tenenhaus;Rajkovic, Aleksandar
通讯作者：
Rajkovic, Aleksandar