CAFFEINE CONTRACTURE
CAFFEINE CONTRACTURE
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DOI：
10.1073/pnas.46.6.897
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发表时间：
1960-01-01
影响因子：
11.1
通讯作者：
SAKAI, T
中科院分区：
文献类型：
--
作者：
CONWAY, D;SAKAI, T
证实了咖啡因激活用等渗K2SO4完全去极化的横纹肌的报道，并且咖啡因也可以激活而不显著改变膜电位。然而，去极化不是正常激活的基本要求的结论是不合理的，因为有效的咖啡因治疗留下了不可逆的变化，表明咖啡因反应远非生理性的。
Reports that caffeine activates cross-striated muscle which has been completely depolarized with isotonic K2SO4 and that caffeine can also activate without a significant change in membrane potential are confirmed. The conclusion, however, that depolarization is not an essential requirement of normal activation is unjustified since effective caffeine treatment leaves behind irreversible changes indicating that the caffeine response is far from being physiological.