Continuous theta burst stimulation of right dorsolateral prefrontal cortex induces changes in impulsivity level
Continuous theta burst stimulation of right dorsolateral prefrontal cortex induces changes in impulsivity level
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DOI：
10.1016/j.brs.2009.10.002
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发表时间：
2010-07-01
影响因子：
7.7
通讯作者：
Strafella, Antonio P.
中科院分区：
文献类型：
--
作者：
Cho, Sang Soo;Ko, Ji Hyun;Strafella, Antonio P.
有证据表明，右背外侧前额叶皮层（DLPFC）可能在与奖励价值和时间知觉相关的决策中发挥一定的作用，特别是在冲动决策的抑制控制中。采用θ爆发刺激（theta burst stimulation，TBS）和延迟折扣（delay discounting，DD）任务，研究了右侧DLPFC在延迟奖励折扣率定义的冲动性决策中的潜在作用。健康的右利手志愿者接受了三次刺激，间歇性TBS（iTBS），连续TBS（cTBS）和假手术。贴现函数（k值）的陡度，选择和一致性的反应时间测量每个科目。与假手术条件相比，DLPFC的cTBS使DD任务的k值降低了36.88%。相反，iTBS并不影响冲动水平。与假刺激相比，iTBS或cTBS后的选择反应时间和一致性均无变化。这些结果表明，cTBS诱导的右侧DLPFC皮质兴奋性的调制可能会影响和减少冲动决策。这些观察结果可能提供一些见解的作用，正确的DLPFC调制冲动水平和计算奖励价值在不同的时间尺度下不太模糊的情况下。(C)2010年爱思唯尔公司All rights reserved.
There is evidence that the right dorsolateral prefrontal cortex (DLPFC) may play a certain role in decision making related to reward value and time perception and, in particular, in the inhibitory control of impulsive decision making. Using the theta burst stimulation (TBS) and a delay discounting (DD) task, we investigated the potential role of right DLPFC in impulsive decision making defined by the rate of discounting delayed reward. Healthy right-handed volunteers underwent three stimulation sessions, intermittent TBS (iTBS), continuous TBS (cTBS), and sham. The steepness of the discount function (k-value), reaction time for choice and consistency were measured for each subjects. cTBS of the DLPFC reduced by 36.88 % the k-value of the DD task compared to sham condition. In contrast, iTBS did not affect impulsivity level. There were no changes neither in reaction time for choice nor consistency after either the iTBS or cTBS compared with the sham stimulation. These results demonstrate that cTBS-induced modulation of cortical excitability of the right DLPFC may affect and reduce impulsive decision making. These observations may provide some insights into the role of the right DLPFC in modulating impulsivity level and calculating reward value at different time scales under less ambiguous circumstances. (C) 2010 Elsevier Inc. All rights reserved.