Common cues regulate neural and vascular patterning
Common cues regulate neural and vascular patterning
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DOI：
10.1016/j.gde.2007.07.004
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发表时间：
2007-08-01
影响因子：
4
通讯作者：
Li, Dean Y.
中科院分区：
文献类型：
--
作者：
Jones, Christopher A.;Li, Dean Y.
神经和血管在穿过身体到达远端目标时通常遵循平行的轨迹。调节轴突引导过程的蛋白质同样被证明在血管迁移中发挥着至关重要的作用。最近将内皮尖端细胞描述为轴突生长锥的类似物，神经血管的类比似乎已经完成。尽管存在这些相当大的相似之处，但神经引导和血管引导之间仍然存在一个关键区别。虽然导航轴突只是一个细胞，但发芽的血管由多个细胞组成，必须协调调节。最近对 D114-Notch1 信号通路的研究为了解脉管系统如何完成这一关键任务提供了宝贵的见解。
Nerves and blood vessels often follow parallel trajectories as they course through the body to their distal targets. Proteins that regulate the process of axon guidance have likewise been shown to play a crucial role in blood vessel migration. With the recent description of the endothelial tip cell as an analog of the axonal growth cone, the nerve-vessel analogy seems complete. Notwithstanding these considerable similarities, one crucial difference remains between neural and vascular guidance. While a navigating axon is but a single cell, a sprouting vessel is composed of multiple cells that must be coordinately regulated. Recent studies of the D114-Notch1 signaling pathway have provided valuable insight into how the vasculature accomplishes this crucial task.