Intersession repeatability of humphrey perimetry measurements in patients with retinitis pigmentosa
Intersession repeatability of humphrey perimetry measurements in patients with retinitis pigmentosa
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DOI：
10.1167/iovs.07-0690
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发表时间：
2007-10-01
影响因子：
4.4
通讯作者：
Fishman, Gerald A.
中科院分区：
文献类型：
--
作者：
Kim, Linda S.;McAnany, J. Jason;Fishman, Gerald A.
目的。探讨色素性视网膜炎（RP）患者静态视野检查间歇试验重复性与局部敏感性降低程度的关系。使用Humphrey field Analyzer的FASTPAC 30-2和刺激尺寸III和v获得27例RP患者的视野数据，每个测试在初始练习后的两次随访中重复。每个患者在视野中每个测量点的间歇灵敏度差是通过在相应的测试位置减去第2阶段获得的灵敏度值来定义的。此外，在每个患者的每个位置，确定疗程2和3的平均敏感性值。时段间灵敏度差异与平均灵敏度的函数关系的Bland-Altman图显示，在灵敏度约为10 dB的测试区域，测试-重测变异性最大，在灵敏度较高或较低的位置，变异性较小。III和V级刺激的结果模式相似。刺激尺寸III的平均间歇灵敏度差为+0.26 dB，刺激尺寸V的平均间歇灵敏度差为+0.45 dB，表明从第2次到第3次的灵敏度有小幅提高。RP患者视野测量的间歇可重复性与灵敏度丧失的程度呈非单调相关。因此，由于时间或治疗而引起的视野灵敏度的明显变化应根据在特定灵敏度水平上的预期变化程度进行评估。
PURPOSE. To determine the relationship between intersession test repeatability in static perimetry and the degree of local sensitivity reduction in patients with retinitis pigmentosa ( RP).METHODS. Visual field data were obtained from 27 patients with RP using FASTPAC 30-2 of the Humphrey Field Analyzer and stimulus sizes III and V. Each test was repeated at two subsequent visits after an initial practice session. An intersession sensitivity difference was defined for each patient at each measured point in the visual field by subtracting the sensitivity value obtained during session 2 from the value obtained during session 3 at the corresponding test location. In addition, the mean sensitivity value for sessions 2 and 3 was determined at each location for each patient.RESULTS. Bland-Altman plots of intersession sensitivity differences as a function of mean sensitivities showed that test-retest variability was greatest at test regions with sensitivities of approximately 10 dB, with lower variability at locations with higher or lower sensitivity. The pattern of findings was similar for sizes III and V stimuli. The mean intersession sensitivity difference was +0.26 dB for stimulus size III and +0.45 dB for stimulus size V, representing a small improvement in sensitivity from session 2 to session 3.CONCLUSIONS. Intersession repeatability of visual field measurements in patients with RP is nonmonotonically related to the magnitude of the sensitivity loss. Therefore, apparent changes in visual field sensitivity as a result of time or treatment should be evaluated in light of the degree of the expected variability at particular sensitivity levels.