Epigenetic dysregulation in follicular lymphoma
Epigenetic dysregulation in follicular lymphoma
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DOI：
10.2217/epi.15.96
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发表时间：
2016-01-01
期刊：
影响因子：
3.8
通讯作者：
Heward, James
中科院分区：
文献类型：
--
作者：
Araf, Shamzah;Okosun, Jessica;Heward, James
采用下一代测序技术导致了我们对滤泡性淋巴瘤遗传格局的理解发生了显着转变。虽然该疾病与t（14; 18）同义，但调节表观基因组的基因改变的流行已被确定为这些淋巴瘤的关键标志。在揭示肿瘤发生中这些改变的生物学后果方面正在取得巨大进展，为定向治疗开辟了新的机会。
The adoption of next-generation sequencing technologies has led to a remarkable shift in our understanding of the genetic landscape of follicular lymphoma. While the disease has been synonymous with the t(14; 18), the prevalence of alterations in genes that regulate the epigenome has been established as a pivotal hallmark of these lymphomas. Giant strides are being made in unraveling the biological consequences of these alterations in tumorigenesis opening up new opportunities for directed therapies.