Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI
Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI
复制标题
DOI：
10.1016/j.joca.2013.03.001
复制
发表时间：
2013-06-01
影响因子：
7
通讯作者：
Nevitt, M. C.
中科院分区：
文献类型：
--
作者：
Felson, D. T.;Niu, J.;Nevitt, M. C.
目的：探讨体育锻炼对无膝关节损伤和膝关节排列的人膝关节骨性关节炎（OA）发展的影响。设计：我们结合多中心骨关节炎（MOST）和骨关节炎倡议（OAI）的数据，研究OA患者或高风险人群。受试者进行了长肢和膝关节后前位x线片检查，并完成了老年人体力活动调查（PASE）。我们的研究对象是没有骨性关节炎的患者，排除了膝部有严重损伤和没有长肢片的患者。我们对受试者进行了30个月（MOST）和48个月（OAI）的随访，观察两种事件结果中的一种：(1)症状性胫股OA（影像学上的OA和膝关节疼痛），或(2)胫股狭窄。“活跃”的人是指按性别划分PASE得分最高的人。我们采用logistic回归对年龄、性别、体重指数（BMI）、西安大略和麦克马斯特关节炎指数（WOMAC）疼痛评分、Kellgren和Lawrence （KL）分级（0或1）和来源研究进行校正，检查了活动组患OA的风险。我们还分析了畸形和正常肢体的膝关节。结果：合并样本包括2073名受试者（3542个膝关节），平均年龄61岁。症状性胫股骨关节炎的累积发生率在活动组为1.12%，在其他组为1.82%（活动组的优势比（OR）为0.6,95%可信区间（CI）为0.3,13）。活动组膝关节关节间隙狭窄发生率为3.41%，其他组为4.04%（活动组OR为0.9 (95% CI 0.5, 1.5)）。结果不因排列状态而异。结论：最高四分位数的体力活动不会影响患OA的风险。(C) 2013年国际骨关节炎学会。Elsevier Ltd.出版。版权所有。
Objective: To determine the effect of physical activity on knee osteoarthritis (OA) development in persons without knee injury and according to knee alignment.Design: We combined data from Multicenter Osteoarthritis (MOST) and Osteoarthritis Initiative (OAI), studies of persons with or at high risk of OA. Subjects had long limb and repeated posteroanterior knee radiographs and completed the physical activity survey for the elderly (PASE). We studied persons without radiographic OA and excluded knees with major injury and without long limb films. We followed subjects 30 months (in MOST) and 48 months (in OAI) for one of two incident outcomes: (1) symptomatic tibiofemoral OA (radiographic OA and knee pain), or (2) tibiofemoral narrowing. 'Active' persons were those with PASE score in the highest quartile by gender. We examined risk of OA in active group using logistic regression adjusting for age, gender, body mass index (BMI), Western Ontario and McMaster Arthritis Index (WOMAC) pain score, Kellgren and Lawrence (KL) grade (0 or 1), and study of origin. We also analyzed knees from malaligned and neutrally aligned limbs.Results: The combined sample comprised 2,073 subjects (3,542 knees) with mean age 61 years. The cumulative incidence of symptomatic tibiofemoral OA was 1.12% in the active group vs 1.82% in the others (odds ratio (OR) among active group 0.6, 95% confidence interval (CI) 0.3, 13). Joint space narrowing occurred in 3.41% of knees in the active group vs 4.04% in the others (OR among active group 0.9 (95% CI 0.5, 1.5)). Results did not differ by alignment status.Conclusions: Physical activity in the highest quartile did not affect the risk of developing OA. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.