Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment
Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment
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DOI：
10.1016/j.neurobiolaging.2004.11.006
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发表时间：
2005-08-01
影响因子：
4.2
通讯作者：
Stoeter, P
中科院分区：
文献类型：
--
作者：
Fellgiebel, A;Müller, MJ;Stoeter, P
不同的过程，如微血管功能障碍，自由基毒性，P-淀粉样蛋白沉积，和沃勒变性可以引起功能相关的脑神经元网络的髓鞘变性的干扰。彩色编码弥散张量成像（ccDTI）允许有髓纤维束的结构识别和定量。特别是，后扣带回纤维束，这被认为是重要的神经元基板的网络代表的记忆处理可以定位只有不精确的常规磁共振imaging techniques.后扣带回束进行了评估，在17例遗忘型轻度认知功能障碍（MCI），25例阿尔茨海默氏痴呆症（DAT），和21个年龄匹配的控制。此外，DTI值与延迟言语回忆测验的记忆成绩相关，MCI组和对照组之间以及DAT组和对照组之间的各向异性分数和平均扩散率差异显著。整个研究组在延迟言语回忆测试中的表现与后扣带回束各向异性和扩散率显著相关，因此，使用ccDTI似乎是检测和量化MCI后扣带回白色物质结构完整性的有利策略。DTI参数的改变证实了白色物质的病理参与MCI的发展。此外，ccDTI可以作为体内方法来研究年龄和疾病相关的髓鞘改变作为认知功能障碍的潜在形态学底物。(c)2004爱思唯尔公司All rights reserved.
Different processes like microvascular dysfunction, free radical toxicity, P-amyloid deposits, and Wallerian degeneration can cause functionally relevant disturbances of cerebral neuronal networks by myelin degeneration. Color-coded diffusion-tensor-imaging (ccDTI) allows the structural identification and quantification of myelinated fiber tracts. Particularly, posterior cingulate fiber tracts, which are regarded as important neuronal substrates of the network representing memory processing can be localized only imprecisely by conventional magnetic resonance imaging techniques.The posterior cingulate bundles were assessed by ccDTI in 17 patients with amnestic mild cognitive impairment (MCI), 25 patients with Alzheimer's dementia (DAT), and 21 age-matched controls. Additionally, DTI values were con-elated with memory performance in the delayed verbal recall test.Fractional anisotropy and mean diffusivity differed significantly between MCI and controls, as well as between DAT and controls. Performance in the delayed verbal recall test of the entire study group correlated significantly with posterior cingulate bundle anisotropy and diffusivity.Using ccDTI seems, hence, a favorable strategy to detect and quantify the structural integrity of posterior cingulate white matter in MCI. Alterations of DTI parameters substantiate the involvement of white matter pathology in the development of MCI. Moreover, ccDTI could serve as in vivo method to investigate age and disease-related myelin alterations as potential morphological substrates of cognitive dysfunction. (c) 2004 Elsevier Inc. All rights reserved.