The use of the orthotopic model to validate antivascular therapies for cancer
The use of the orthotopic model to validate antivascular therapies for cancer
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DOI：
10.1387/ijdb.103230ml
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发表时间：
2011-01-01
影响因子：
0.7
通讯作者：
Pastorino, Fabio
中科院分区：
文献类型：
--
作者：
Loi, Monica;Di Paolo, Daniela;Pastorino, Fabio
原位模型再现了肿瘤微环境的各个方面，并模拟了癌症进展、血管生成、转移和耐药性的许多重要生物学特征。由于其与人类癌症相似，该模型可用于评估对各种疗法的治疗反应。这篇综述概述了在小鼠模型中使用肿瘤细胞原位植入来评估抗血管治疗有效性的重要性。
The orthotopic model reproduces aspects of the tumour microenvironment and emulates a number of important biological features of cancer progression, angiogenesis, metastasis and resistance. Due to its parallels with human cancer, the model can be used to evaluate therapeutic responses to various therapies. This review outlines the importance of using the orthotopic implantation of tumour cells in mice models for evaluating the effectiveness of antivascular therapies.