Spectral sensitivity and color discrimination changes in glaucoma and glaucoma-suspect patients.
Spectral sensitivity and color discrimination changes in glaucoma and glaucoma-suspect patients.
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发表时间：
1982-10
影响因子：
4.4
通讯作者：
Anthony J. Adams;Rosemary Rodic;R. Husted;Robert;Stamper
中科院分区：
文献类型：
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作者：
Anthony J. Adams;Rosemary Rodic;R. Husted;Robert;Stamper
色觉改变可能发生在青光眼病程的早期，并可能先于视野丧失。青光眼怀疑者，眼内压升高，没有诊断性视神经乳头或视野改变，也可能有色觉丧失。不幸的是，在研究中使用的仪器已经证明了这些色觉的变化是不可行的常规临床使用;同样，研究没有仔细控制小瞳孔大小和年龄的影响，或没有指出负责的潜在机制。我们通过Farnsworth D-15小组测试（D-15测试的去饱和版本）和光谱增量阈值的测量，研究了每组的19名青光眼患者、19名青光眼疑似患者和年龄匹配的对照组。Farnsworth D-15面板测试的微小修改产生高度显着的青光眼和青光眼疑似患者与年龄匹配的正常组之间的差异。此外，光谱增量阈值，与两个度的光谱目标闪烁在明亮的白色背景上的1或25赫兹，表明消色差和彩色灵敏度显着降低时，与他们的年龄匹配的正常。瞳孔大小似乎不是一个重要因素。这些结果表明，两种不同的神经节细胞群的功能受到影响，青光眼可能会产生功能丧失的中央凹区的疾病过程中比以前认为的更早。
Color vision changes may occur early in the course of glaucoma and may precede visual field loss. Glaucoma suspects, having raised intraocular pressure and no diagnostic optic nerve head or visual field changes, may also have color vision loss. Unfortunately, the instruments used in the studies that have demonstrated these color vision changes were not feasible for routine clinical use; likewise, the studies did not carefully control for the effects of small pupil size and age or did not point to the underlying mechanisms responsible. We studied 19 glaucoma patients, 19 glaucoma suspects, and age-matched controls for each group by means of the Farnsworth D-15 panel test, a desaturated version of the D-15 test, and by measures of spectral increment threshold. Minor modifications of the Farnsworth D-15 panel test produce highly significant differentiation of glaucoma and glaucoma-suspect patients from age-matched normal groups. Further, spectral increment thresholds, with a two-degree spectral target flashed at either 1 or 25 Hz on a bright white background, show that both achromatic and chromatic sensitivity are significantly reduced when compared with their age-matched normals. Pupil size does not seem to be a significant factor. These results suggest that the function of two different ganglion cell populations is affected in glaucoma and that glaucoma may produce functional loss in the central foveal area earlier in the disease process than previously believed.