Divaricamine A, a new anti-malarial trimeric monoterpenoid indole alkaloid from Tabernaemontana divaricata
Divaricamine A, a new anti-malarial trimeric monoterpenoid indole alkaloid from Tabernaemontana divaricata
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DOI：
10.1016/j.tetlet.2021.153423
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发表时间：
2021-10-31
影响因子：
1.8
通讯作者：
Morita, Hiroshi
中科院分区：
文献类型：
--
作者：
Hirasawa, Yusuke;Yasuda, Reina;Morita, Hiroshi
从狗牙花（Tabernaemontana divaricata）的根中分离出一种新的三聚单萜吲哚生物碱——狗牙花胺A（1），其具有长春胺 - 长春胺 - 伊波加型骨架。通过二维核磁共振数据和圆二色谱确定了包括绝对立体化学在内的结构。狗牙花胺A（1）显示出强大的抗疟疾活性。（C）2021爱思唯尔有限公司。保留所有权利。
A new trimeric monoterpenoid indole alkaloid, divaricamine A (1) consisting of a vobasine-vobasine-iboga type skeleton, was isolated from the root of Tabernaemontana divaricata. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and CD spectrum. Divaricamine A (1) showed potent anti-malarial activity. (C) 2021 Elsevier Ltd. All rights reserved.