THE EFFECTS OF ETHANOL ON THE CLEARANCE OF ESTRADIOL IN POSTMENOPAUSAL WOMEN
THE EFFECTS OF ETHANOL ON THE CLEARANCE OF ESTRADIOL IN POSTMENOPAUSAL WOMEN
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DOI：
10.1016/s0015-0282(16)57602-x
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发表时间：
1995-06-01
影响因子：
6.7
通讯作者：
BARBIERI, RL
中科院分区：
文献类型：
--
作者：
GINSBURG, ES;WALSH, BW;BARBIERI, RL
目的：为了确定急性酒精摄入是否影响去除透皮E2贴剂后循环E2水平下降的模式。设计：一项随机、安慰剂对照、交叉研究。设置：该研究在布里格姆妇女医院的临床研究中心进行。参与者：12名健康的绝经后妇女入选。干预措施：在受试者摄入酒精（1 mL/kg 95%乙醇）或碳水化合物安慰剂之前13小时，使用0.15 mg透皮E（2）贴剂。主要结果测量：E2，雌酮（E（1）），和乙醇的水平measured.Results：血清样品获得了40分钟前饮用和饮用后5小时和E（2）贴片去除饮料inguish.Main结果测量：E2，雌酮（E（1）），和乙醇levels. Results：在去除贴片时，E（2）水平在10分钟内急剧上升，然后迅速下降，这表明摄入乙醇后的推注效应更加明显。摄入乙醇并去除贴片后，E（2）的半衰期计算为378分钟，摄入碳水化合物并去除贴片后为245分钟。有没有显着的变化，E（1）浓度在研究的时间进程之间groups.Conclusions：乙醇摄入可能会降低E（2）清除后，去除透皮E（2）贴剂。
Objective: To determine whether acute alcohol ingestion affects the pattern of decline of circulating E(2) levels after removal of transdermal E(2) patches.Design: A randomized, placebo-controlled, crossover study.Setting: The study was performed in the Clinical Research Center of the Brigham and Women's Hospital.Participants: Twelve healthy postmenopausal women were enrolled.Interventions: Transdermal E(2) patches, 0.15 mg, were applied 13 hours before subjects ingested alcohol (1 mL/kg 95% ethanol) or carbohydrate placebo punch. The patches were removed immediately after drink ingestion.Main Outcome Measures: Estradiol, estrone (E(1)), and ethanol levels were measured.Results: Serum samples were obtained for 40 minutes before drink ingestion and 5 hours after drink ingestion and E(2) patch removal. At the time of patch removal, E(2) levels rose acutely over 10 minutes and then decreased rapidly, suggesting a bolus effect that was more marked after ethanol ingestion. After ethanol ingestion and patch removal the half-life of E(2) was calculated to be 378 minutes, and after carbohydrate punch and patch removal 245 minutes. There were no significant changes in E(1) concentrations over the time course of the study between groups.Conclusions: Ethanol ingestion may decrease E(2) clearance after removal of transdermal E(2) patches.