OSTEOPONTIN AND RELATED PHOSPHORYLATED SIALOPROTEINS - EFFECTS ON MINERALIZATION
OSTEOPONTIN AND RELATED PHOSPHORYLATED SIALOPROTEINS - EFFECTS ON MINERALIZATION
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DOI：
10.1111/j.1749-6632.1995.tb44635.x
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发表时间：
1995-01-01
期刊：
影响因子：
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通讯作者：
BOSKEY, AL
中科院分区：
文献类型：
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作者：
BOSKEY, AL
骨桥蛋白是在矿化结缔组织的细胞外基质中发现的磷酸化唾液酸蛋白家族之一。来自各种实验室的溶液研究表明，虽然这些蛋白质中的一些（例如骨桥蛋白、牙本质唾液蛋白）抑制磷酸钙的产生，但其他蛋白质（例如骨唾液蛋白）可以作为磷酸钙形成的成核剂。这些蛋白质行为的差异可能与它们与矿物晶核和晶体生长位点的相互作用有关。反过来，这些相互作用的特异性可能与唾液蛋白一级结构的差异以及它们被磷酸化的程度有关。骨桥蛋白和骨桥蛋白相关蛋白对矿物质沉积的影响的体外研究系统进行了描述，沿着与机制解释的对比能力的聚谷氨酸盐的骨唾液酸蛋白作为成核剂，而聚谷氨酸盐的骨桥蛋白和牙本质唾液酸蛋白抑制磷酸钙的形成和生长。
Osteopontin is one of a family of phosphorylated sialoproteins found in the extracellular matrices of mineralized connective tissues. Solution studies from a variety of laboratories have shown that while some of these proteins (eg, osteopontin, dentin sialoprotein) inhibit calcium phosphate production, others, such as bone sialoprotein, can act as a nucleator of calcium phosphate formation. The differences in the behaviors of these proteins can be related to their interactions with mineral crystal nuclei and crystal growth sites. The specificity of these interactions, in turn, can be related to differences in the primary structures of the sialoproteins and to the extent to which they are phosphorylated. In vitro systems for the study of osteopontins and osteopontin-related protein effects on mineral deposition are described, along with mechanisms explaining the contrasting abilities of the polyglutamate-containing bone sialoprotein to act as a nucleator, while the polyaspartate-containing osteopontin and dentin sialoproteins inhibit calcium phosphate formation and growth.