Effects of lactoferrin and lactoperoxidase-containing food on the oral hygiene status of older individuals: A randomized, double blinded, placebo-controlled clinical trial
Effects of lactoferrin and lactoperoxidase-containing food on the oral hygiene status of older individuals: A randomized, double blinded, placebo-controlled clinical trial
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含乳铁蛋白和乳过氧化物酶的食物对老年人口腔卫生状况的影响：一项随机、双盲、安慰剂对照临床试验
DOI：
10.1111/ggi.12776
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发表时间：
2017
影响因子：
3.3
通讯作者：
Hironaka S
中科院分区：
文献类型：
--
作者：
Morita Y;Ishikawa K;Nakano M;Wakabayashi H;Yamauchi K;Abe F;Ooka T;Hironaka S
乳铁蛋白和乳过氧化物酶对口腔病原菌具有抗菌作用。这项随机、双盲、安慰剂对照的平行组研究测试了含乳铁蛋白和乳过氧化酶片（LF + LPO片）改善老年人口腔卫生状况的疗效。方法共46名参与者（31名养老院居民和15名健康老年人）被随机分配服用含乳铁蛋白和乳过氧化物酶片或安慰剂片，并被要求在每餐后吮吸一片，持续8周。在基线、4周和8周进行口腔和细菌学评估。结果共纳入47例患者，试验组20例，平均年龄80.4±6.4岁；安慰剂组17例，平均年龄85.9±6.7岁。试验组4周和8周舌苔细菌总数较基线显著减少，8周牙龈卟啉单胞菌和核梭杆菌数量显著减少。细菌总数和p的数量。牙龈上菌斑的牙龈素在8周时明显减少。此外，p的数量变化也有显著差异。两组在8周时牙龈上菌斑的差异。结论乳铁蛋白和乳过氧化酶片对舌苔和龈上菌斑内的牙周细菌有一定的抗菌作用，提示长期服用乳铁蛋白和乳过氧化酶片可改善老年人口腔卫生。Geriatr Gerontol Int 2017；17: 714 - 721。
AimLactoferrin and lactoperoxidase have antimicrobial effects against oral pathogens. This randomized, double‐blinded, placebo‐controlled parallel group study tested the efficacy of a lactoferrin and lactoperoxidase‐containing tablet (LF + LPO tablet) in improving the oral hygiene status of older individuals.MethodsA total of 46 participants (31 nursing home residents and 15 healthy older individuals) were randomly assigned to receive either lactoferrin and lactoperoxidase‐containing tablets or placebo tablets, and were asked to suck on a tablet after every meal for 8 weeks. Oral and bacteriological assessments were carried out at baseline, 4 weeks and 8 weeks.ResultsA total of 47 participants (test groupn= 20; mean age 80.4 ± 6.4 years; placebo groupn= 17; mean age 85.9 ± 6.7 years) were included in the efficacy analysis. In the test group, the total number of bacteria in the tongue coating was significantly reduced at 4 and 8 weeks compared with that at baseline, and the number ofPorphyromonas gingivalisandFusobacterium nucleatumwas significantly reduced at 8 weeks. The total number of bacteria and the number ofP. gingivalisin the supragingival plaque were significantly reduced at 8 weeks. Furthermore, there was a significant difference in the change in the number ofP. gingivalisin supragingival plaque at 8 weeks between the two groups.ConclusionsLactoferrin and lactoperoxidase‐containing tablet ingestion showed antibacterial effects on periodontal bacteria present in the tongue coating and supragingival plaque, indicating that long‐term ingestion could improve the oral hygiene of older individuals.Geriatr Gerontol Int 2017; 17: 714–721.