Deposition of Particles in Human Mouth-Throat Replicas and a USP Induction Port.
Deposition of Particles in Human Mouth-Throat Replicas and a USP Induction Port.
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DOI：
10.1089/jamp.2013.1105
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发表时间：
2014-08
影响因子：
3.4
通讯作者：
Yung-sung Cheng;Yue Zhou;W. Su
中科院分区：
文献类型：
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作者：
Yung-sung Cheng;Yue Zhou;W. Su
研究背景口腔吸入是药物进入肺内呼吸道的常见途径。一般来说，药物输送装置在口咽呼吸道中的沉积占发射剂量的很大一部分，这会影响向肺部输送的剂量。对身体或磁共振成像扫描制成的呼吸道复制品的研究表明，对于微米大小的颗粒，撞击是主要的沉积机制。在口咽复制品中的几项沉积研究发现，沉积效率可以与口腔入口速度和入口口罩直径相关。其他研究表明，沉积效率与内部几何形状的平均直径和基于平均直径的平均速度相关性最好。方法根据本研究的实验数据，研究口腔入口直径、内气道大小及其对口咽沉积的影响。使用了几个具有不同口腔入口直径和USP诱导口的口咽部复制品。结果气溶胶沉降量随入口直径的减小而增大。根据(1)口腔入口直径和入口速度，(2)内部几何形状的平均直径和平均速度，(3)口腔入口速度和平均直径，(4)口腔入口速度和口咽复制品的最小直径，计算出沉积效率与斯托克斯数之间的关系。病例4的相关性最好。结论这种相关性可以解释在某些气雾剂给药装置中，当沉积随口腔入口直径而变化时，受试者内部的变化。这也可以解释当研究具有不同呼吸道几何形状和张口的人类志愿者时，口咽沉积的受试者之间的差异。
BACKGROUND Oral inhalation is the common route of drug delivery to pulmonary airways. In general, deposition in the oropharyngeal airways from a drug-delivery device makes up a substantial portion of the emitted dose, which affects the dose delivered to the lung. Studies with airway replicas made from cadaver or magnetic resonance imaging scans show that for micrometer-sized particles, impaction is the dominant deposition mechanism. Several deposition studies in oropharyngeal replicas found that the deposition efficiency can be correlated with the mouth inlet velocity and inlet mouthpiece diameter. Other studies show that the deposition efficiency is best correlated with the mean diameter of internal geometry and the mean velocity based on the mean diameter. METHOD We investigated the mouth inlet diameter, as well as internal airway dimensions and their influence on oropharyngeal deposition based on experimental data from this study. Several human oropharyngeal replicas with different mouth inlet diameters and the USP induction port were used. RESULTS We found that the aerosol deposition increased with decreasing mouth inlet diameter. Several mathematical expressions were tried to correlate the deposition efficiency with the Stokes number calculated based on (1) mouth inlet diameter and inlet velocity, (2) mean diameter of internal geometry and mean velocity, (3) mouth inlet velocity and mean diameter, and (4) mouth inlet velocity and minimum diameter in the oropharyngeal replica. The best correlation was obtained in case 4. CONCLUSIONS This correlation could explain the intra-subject variation when deposition was found to vary with mouth inlet diameter, such as in some aerosol drug-delivery devices. It could also explain the intersubject variability in oropharyngeal deposition when human volunteers with different airway geometries and mouth openings were studied.